Priming effect of misoprostol on estrogen pretreated cervix in postmenopausal women

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dc.contributor.authorAtmaca, R
dc.contributor.authorKafkasli, A
dc.contributor.authorBurak, F
dc.contributor.authorGermen, AT
dc.date.accessioned2024-08-04T20:14:48Z
dc.date.available2024-08-04T20:14:48Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMisoprostol, which is a prostaglandin E1 analogue, is effectively used in cervical priming in women both for labor induction and for gynecological procedures. Although its efficacy is well documented in reproductive age women, during postmenopausal period this efficacy is limited probably due to estrogen deficit. Our objective is to evaluate if estrogen deficit in postmenopausal women is important for the effect of misoprostol on cervical ripening before diagnostic procedures. In this study, 45 patients were randomly allocated to estrogen or placebo group. The study group received local estrogen cream and other group received chlindamycine phosphate cream as placebo. The patients were given oral misoprostol 24 and 12 hours before the procedure for uterine cavity evaluation. Cervix was dilated by using Heagar dilator up to 6 mm. Data were analyzed by Student t-test, Mann-Whitney's U-test, chi-square test and paired samples t-test where appropriate. Basal cervical widths for the estrogen and placebo groups were 4.4 +/- 0.7 and 3.7 +/- 0.7 mm, respectively (p < 0.01). Mean time required for dilatation of cervix was 44.4 +/- 16.2 seconds for the estrogen group and 61.4 +/- 18.3 seconds for the placebo group (p < 0.01). As a conclusion, misoprostol treatment alone is not effective to get cervical priming in postmenopausal women, and as shown in our study, pretreatment with local estrogen overcome the failure. To get a beneficial effect of misoprostol on cervical ripening, estrogenic activity is necessary and when pretreated with local estrogen, misoprostol ameliorates cervical priming in postmenopausal women. (c) 2005 Tohoku University Medical Press.en_US
dc.identifier.doi10.1620/tjem.206.237
dc.identifier.endpage241en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue3en_US
dc.identifier.pmid15942151en_US
dc.identifier.scopus2-s2.0-21244469859en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage237en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.206.237
dc.identifier.urihttps://hdl.handle.net/11616/93979
dc.identifier.volume206en_US
dc.identifier.wosWOS:000229760700008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmisoprostolen_US
dc.subjectpostmenopausal womenen_US
dc.subjectcervical ripeningen_US
dc.subjectestrogenen_US
dc.titlePriming effect of misoprostol on estrogen pretreated cervix in postmenopausal womenen_US
dc.typeArticleen_US

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