Investigation of biological effects of some Mannich Bases containing Bis-1,2,4-Triazole

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dc.authoridKaratepe, Mustafa/0000-0001-6358-5913
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridPARLAK, AKIF EVREN/0000-0002-2579-9985
dc.authoridKoparir, Metin/0000-0003-1031-783X
dc.authoridTurkoglu, Semra/0000-0001-7682-0513;
dc.authorwosidKaratepe, Mustafa/HII-5655-2022
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidPARLAK, AKIF EVREN/GNO-9528-2022
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidKoparir, Metin/W-7674-2018
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidTurkoglu, Semra/V-6190-2018
dc.contributor.authorParlak, A. E.
dc.contributor.authorCelik, S.
dc.contributor.authorKaratepe, M.
dc.contributor.authorTurkoglu, S.
dc.contributor.authorAlayunt, N. O.
dc.contributor.authorDastan, S. D.
dc.contributor.authorUlas, M.
dc.date.accessioned2024-08-04T20:42:45Z
dc.date.available2024-08-04T20:42:45Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, the effects of Mannich bases containing bis-1,2,4-triazole on the levels of in vivo malondialdehyde (MDA) and antioxidant vitamins (A, E, C) were examined in serum, livers and kidneys of rats. DA and vitamin (A, E, C) levels were determined by high performance liquid chromatography (HPLC). Antioxidant effect was investigated by determining the MDA levels in Saccharomyces cerevisiae cells as in vitro. Furthermore, the antitumor effects of compounds were investigated against MCF-7 human breast cancer cells. Interrelations of results among control and compound groups were evaluated using SPSS statistical software package. As a result, some of the compounds showed effective biological activity when compared to control conditions. The test compounds used in this study may be effective for utilization in the selection and design of model compounds for further studies.en_US
dc.identifier.doi10.14715/cmb/2016.62.7.9
dc.identifier.endpage54en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue7en_US
dc.identifier.pmid27453272en_US
dc.identifier.scopus2-s2.0-84994841024en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage46en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2016.62.7.9
dc.identifier.urihttps://hdl.handle.net/11616/97574
dc.identifier.volume62en_US
dc.identifier.wosWOS:000386768700009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherC M B Assocen_US
dc.relation.ispartofCellular and Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMannich basesen_US
dc.subject1,2,4-triazoleen_US
dc.subjectBiological activityen_US
dc.titleInvestigation of biological effects of some Mannich Bases containing Bis-1,2,4-Triazoleen_US
dc.typeArticleen_US

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