Comparison of the Protective Effects of Prostaglandin Analogues in the Ischemia and Reperfusion Model of Rabbit Eyes

Basit Öğe Kaydı
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridEmre, Sinan/0000-0002-9788-3895
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridYesilada, Elif/0000-0002-3743-5767
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidEmre, Sinan/T-5643-2019
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidERDOĞAN, Ali/ABG-8548-2020
dc.authorwosidYesilada, Elif/ABG-9600-2020
dc.contributor.authorEmre, Sinan
dc.contributor.authorGul, Mehmet
dc.contributor.authorAtes, Burhan
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorKoc, Bekir
dc.contributor.authorErdogan, Ali
dc.contributor.authorYesilada, Elif
dc.date.accessioned2024-08-04T20:32:14Z
dc.date.available2024-08-04T20:32:14Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was planned to investigate the neuroprotective potentials of three commercially available prostaglandin analogues (PGA), in the ischemia and reperfusion model (I/R). Thirty New Zealand rabbits were divided into 5 groups and except for the control group (non-ischemic, non-treated), 0.9% NaCl, bimatoprost, latanoprost, or travoprost were applied to both eyes of animals of the respective groups for 1 week. At the end of treatment, ischemia was induced in both eyes of the 4 treatment groups by anterior chamber irrigation of the animals for 60 min. Following 24 h reperfusion, the animals were sacrified. Enucleated eyes and retinal tissues were investigated by light microscopy, electron microscopy, immunohistochemicstry for retinal histopathology, intracellular and apoptotic cells and by retinal morphometry. Vitreous samples were biochemically investigated for probable role of reactive oxygen species, by measuring xanthine oxidase (XO) activity. Analysis of morphometric measurements and vitreous XO activity revealed significant differences between the PGA-treated groups and the NaCl-treated group (P<0.05). Similarly, apoptotic cell counts in different retinal layers showed that PGA-treated groups had fewer apoptotic cells in all retinal layers than the NaCl-treated ischemic group (P<0.05). PGA may have high protective potential for different retinal layers and cells. Biochemical analysis of vitreous showed that all PGAs decreased vitreous XO activity significantly compared to the NaCl-treated group (P<0.05). However we could not find any statistically significant differences among the analogues. PGAs may reduce the injury induced by I/R, through the inhibition of XO activity, and it seems that their effects are elicited through numerous pathways.en_US
dc.description.sponsorshipInonu University Scientific Research Fund [2007-12]en_US
dc.description.sponsorshipAuthors have no financial or proprietary interest in any instrument or products used in this study. This study is supported by Inonu University Scientific Research Fund (2007-12).en_US
dc.identifier.doi10.1538/expanim.58.505
dc.identifier.endpage513en_US
dc.identifier.issn1341-1357
dc.identifier.issn1881-7122
dc.identifier.issue5en_US
dc.identifier.pmid19897934en_US
dc.identifier.scopus2-s2.0-73249138540en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage505en_US
dc.identifier.urihttps://doi.org/10.1538/expanim.58.505
dc.identifier.urihttps://hdl.handle.net/11616/94937
dc.identifier.volume58en_US
dc.identifier.wosWOS:000271225000008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInt Press Editing Centre Incen_US
dc.relation.ispartofExperimental Animalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbimatoprosten_US
dc.subjectischemia and reperfusionen_US
dc.subjectlatanoprosten_US
dc.subjecttravoprosten_US
dc.subjectxanthine oxidaseen_US
dc.titleComparison of the Protective Effects of Prostaglandin Analogues in the Ischemia and Reperfusion Model of Rabbit Eyesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu