Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects

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dc.authorid3304en_US
dc.authorid113274en_US
dc.contributor.authorKarademir, Selmin
dc.contributor.authorOğuz, Deniz
dc.contributor.authorŞenocak, Filiz
dc.contributor.authorÖcal, Burhan
dc.contributor.authorKarakurt, Cemşit
dc.contributor.authorÇabuk, Feryal
dc.date.accessioned2018-01-30T05:19:13Z
dc.date.available2018-01-30T05:19:13Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.descriptionPediatrics International (2003) 45 , 676–679.en_US
dc.description.abstractBackground : The arthritis of rheumatic fever is very responsive to treatment with salicylates, but there aremany adverse reactions, especially hepatotoxicity, due to aspirin (acetylsalicylic acid) therapy. These side-effects change the course and duration of rheumatic fever. Other non-steroidal anti-inflammatory drugs maybe equally effective, although no reports are available. Methods : We studied 72 patients with rheumatic fever who were admitted to Dr Sami Ulus Children’s Hospitalbetween 1995 and 1999. Twenty patients with arthritis were treated with tolmetin (25 mg/kg per day; group I)and 52 patients with arthritis and/or mild carditis were put on aspirin therapy (75–100 mg/kg per day) for 4–6weeks (group II). Arthritis had disappeared at the same time in both the aspirin and tolmetin groups (P = 0.675). Results : The erythrocyte sedimentation rates of patients upon admission, at the first week and at the end oftherapy were not different in the two groups (P > 0.05). No adverse effect of tolmetin therapy was observed,whereas side-effects of salicylate were observed in 19 patients (36.5%) in the aspirin group. Hepatotoxicity,gastric irritation and salicylism were found in 16, four and three patients, respectively. Renal toxicity andReye syndrome were not demonstrated. Because of these side-effects of aspirin, therapy had to be stopped for10–20 days and the duration of hospitalization in this group was lengthened unnecessarily. Conclusion : Tolmetin was safe and effective treatment for arthritic rheumatic fever patients without carditis.Tolmetin can be used particularly in patients who cannot tolerate aspirin.en_US
dc.identifier.citationKarademir, S., Oğuz, D., Şenocak, F., Öcal, B., Karakurt, C., Cabuk, F. (2009). Tolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effects. Pediatrics International.en_US
dc.identifier.doi10.1111/j.1442-200X.2003.01801.xen_US
dc.identifier.endpage0en_US
dc.identifier.issue0en_US
dc.identifier.startpage0en_US
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1111/j.1442-200X.2003.01801.x/epdf
dc.identifier.urihttps://hdl.handle.net/11616/8028
dc.identifier.volume0en_US
dc.language.isoenen_US
dc.publisherPediatrics Internationalen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAspirinen_US
dc.subjectRheumatic feveren_US
dc.subjectTolmetinen_US
dc.titleTolmetin and salicylate therapy in acute rheumatic fever Comparison of clinical efficacy and side effectsen_US
dc.typeArticleen_US

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