The methanolic extract of Thymus praecox subsp. skorpilii var. skorpilii restores glucose homeostasis, ameliorates insulin resistance and improves pancreatic ?-cell function on streptozotocin/nicotinamide-induced type 2 diabetic rats

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dc.authoridAlan, Saadet/0000-0003-2329-151X
dc.authoridtaskin, turgut/0000-0001-8475-6478
dc.authoridCAM, Muhammet Emin/0000-0001-5398-6801
dc.authoridAYAZ ADAKUL, Betul/0000-0003-0752-124X
dc.authorwosidAlan, Saadet/ABH-4282-2020
dc.authorwosidHAZAR-YAVUZ, AYSE NUR/AAA-9174-2019
dc.authorwosidCAM, Muhammet Emin/A-6631-2018
dc.authorwosidErtas, Busra/IQS-8337-2023
dc.authorwosidtaskin, turgut/AAE-4680-2020
dc.authorwosidCAM, Muhammet Emin/AAB-4488-2019
dc.contributor.authorCam, Muhammet Emin
dc.contributor.authorHazar-Yavuz, Ayse Nur
dc.contributor.authorYildiz, Sila
dc.contributor.authorErtas, Busra
dc.contributor.authorAdakul, Betul Ayaz
dc.contributor.authorTaskin, Turgut
dc.contributor.authorAlan, Saadet
dc.date.accessioned2024-08-04T20:45:32Z
dc.date.available2024-08-04T20:45:32Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractEthnopharmacological relevance: Thymus praecox subsp. skorpilii var. skorpilii (syn. Thymus praecox subsp. jankae (Celak.) Jalas) is consumed as a Turkish folk medicine for the treatment of spasm, sore throat and shortness of breath, also having strong antioxidant activity and the leaves of the plant have been utilized for the treatment of diabetes as the decoction in Turkey. Aim of the study: In the present study, we aimed to investigate the potential mechanism of antidiabetic action of Thymus praecox subsp. skorpilii var. skorpilii methanolic extract (TPSE) on streptozotocin (STZ)/nicotinamide (NA)-induced type 2 diabetic rats. Materials and methods: Sprague Dawley rats were randomly divided into four groups; control, diabetes, TPSE (100 mg/kg b.w, p.o.) and metformin group (400 mg/kg b.w, p.o.). Diabetes was established in all groups except control group by 55 mg/kg STZ (i.p.) for once 15 min after 100 mg/kg NA injection. 3 days after STZ/NA injection, treatments were administered for three weeks and then rats were decapitated; tissue and blood samples were obtained for measuring the level of glucose transporters (both GLUTs and sodium glucose co-transporters (SGLTs)), enzymes related to glucose (Hexokinase (HK), phosphoenolpyruvate carboxykinase (PEPCK), alpha-glucosidase) and lipid metabolism (Acetyl-coenzyme carboxylase (ACC)), AST, ALT, creatinine, insulin, anti-inflammatory (IL-10) and inflammatory (TNF-alpha, IL-1 beta, IL-6) cytokines, AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma (PPAR-gamma) and glucagon like peptide-1 (GLP-1). Histopathological alterations of the pancreas were examined. Results: After three weeks of treatment, TPSE has exhibited a significant reduction of plasma levels of the proinflammatory cytokines. Besides, TPSE treatment elevated plasma insulin levels and normalized blood glucose levels. Moreover, it improved the values of AMPK in liver and GLP-1 in pancreas. Increased a-glucosidase, PEPCK, GLUT-2 and SGLTs levels with the induction of diabetes considerably lowered with TPSE treatment. Especially on SGLT-2, TPSE achieved a more prominent decrease. After the atrophy in Langerhans islets due toen_US
dc.description.sponsorshipMarmara University, Scientific Research Projects Committee (MU-BAPKO) [SAG-C-DRP-250416-0173]en_US
dc.description.sponsorshipThis study was supported by Marmara University, Scientific Research Projects Committee (MU-BAPKO; SAG-C-DRP-250416-0173).en_US
dc.identifier.doi10.1016/j.jep.2018.10.028
dc.identifier.endpage38en_US
dc.identifier.issn0378-8741
dc.identifier.issn1872-7573
dc.identifier.pmid30399410en_US
dc.identifier.scopus2-s2.0-85056621529en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.1016/j.jep.2018.10.028
dc.identifier.urihttps://hdl.handle.net/11616/98536
dc.identifier.volume231en_US
dc.identifier.wosWOS:000455692600004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofJournal of Ethnopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectMetabolismen_US
dc.subjectInflammationen_US
dc.subjectThymus praecoxen_US
dc.subjectSTZ/NAen_US
dc.subjectMedicinal plantsen_US
dc.subjectGLUTsen_US
dc.subjectSGLTsen_US
dc.subjectAMPKen_US
dc.titleThe methanolic extract of Thymus praecox subsp. skorpilii var. skorpilii restores glucose homeostasis, ameliorates insulin resistance and improves pancreatic ?-cell function on streptozotocin/nicotinamide-induced type 2 diabetic ratsen_US
dc.typeArticleen_US

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