Candida albicans outbreak associated with total parenteral nutrition in the neonatal unit

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dc.authoridOTLU, BARIS/0000-0002-6220-0521;
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidBerktaş, Mustafa/ABD-1302-2021
dc.contributor.authorGuducuoglu, H.
dc.contributor.authorGultepe, B.
dc.contributor.authorOtlu, B.
dc.contributor.authorBektas, A.
dc.contributor.authorYildirim, O.
dc.contributor.authorTuncer, O.
dc.contributor.authorBerktas, M.
dc.date.accessioned2024-08-04T20:41:46Z
dc.date.available2024-08-04T20:41:46Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The most frequently isolated fungi in patients using TPN belongs to the Candida genus. Various infections including venous catheter infections, fungemia, endocarditis and ophthalmitis may be encountered. Objective: Upon growth of Candida in the blood cultures from the pediatric (neonatal) unit of our hospital, a surveillance was performed in this unit and involving the health care workers. Clonal relationships of the isolates were investigated with molecular tests. Methods: Blood samples obtained from the patients in pediatric neonatal unit were studied with automatized blood culture [BacT/Alert (Bio Merioux, France)]. Yeast isolates from environmental surveillance cultures (TPN solutions, hands of healthcare personnel, etagere, etc) and patients were identified as C. albicans with conventional methods and ID 32 C and ATB (TM) Fungus 3 (Biomerieux, France) kits. Clonal similarity was determined by using AP-PCR as initial method and we have also typified all strains by the method of REP-PCR (diversilab system, bioMerieux). Finally; Pulsed Field Gel Electrophoresis (PFGE) was used for confirmation. Results: C. albicans was isolated in blood cultures of seven patients. Similar antifungal susceptibility patterns were observed in all isolates. AP-PCR and REP-PCR showed that the C. albicans isolates grown in the TPN solution and from the patients' blood cultures were clonally same strains. PFGE analysis further confirmed this clonality. Conclusion: According to results of the molecular methods, we thought that a C. albicans outbreak had occurred in the neonatal pediatric unit, due to contamination of TPN solution.en_US
dc.identifier.doi10.4103/0255-0857.180303
dc.identifier.endpage207en_US
dc.identifier.issn0255-0857
dc.identifier.issn1998-3646
dc.identifier.issue2en_US
dc.identifier.pmid27080773en_US
dc.identifier.scopus2-s2.0-84969758883en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage202en_US
dc.identifier.urihttps://doi.org/10.4103/0255-0857.180303
dc.identifier.urihttps://hdl.handle.net/11616/97333
dc.identifier.volume34en_US
dc.identifier.wosWOS:000378536300014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofIndian Journal of Medical Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCandida albicansen_US
dc.subjectfungal infectionen_US
dc.subjectneonatal uniten_US
dc.subjectparenteral nutritionen_US
dc.titleCandida albicans outbreak associated with total parenteral nutrition in the neonatal uniten_US
dc.typeArticleen_US

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