Nuclear transcription factor-kappa beta-dependent ultrastructural alterations within the placenta and systemic inflammatory activation in pregnant patients with hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome: a case-control study

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridDüz, Senem Arda/0000-0002-9325-7993
dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridAYDIN, Nasuhi/0000-0003-3145-2432
dc.authorwosidAYDIN, Nasuhi Engin/L-1607-2019
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.authorwosidSimsek, Yavuz/AAH-9894-2021
dc.authorwosidAydin, Nasuhi E/B-6536-2012
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.contributor.authorSimsek, Yavuz
dc.contributor.authorGul, Mehmet
dc.contributor.authorCelik, Onder
dc.contributor.authorAydin, Nasuhi Engin
dc.contributor.authorDuz, Senem Arda
dc.contributor.authorCelik, Ebru
dc.contributor.authorOzerol, Elif
dc.date.accessioned2024-08-04T20:37:45Z
dc.date.available2024-08-04T20:37:45Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Preeclampsia appears to be associated with a higher extent of inflammation than in uncomplicated pregnancies. We aimed to test whether this was the case in patients with hemolysis, elevated liver functions and low platelet count (HELLP) syndrome and to clarify the contribution of placental and systemic inflammatory variables in the development of this syndrome. Materials and methods: Thirty healthy pregnant women (control group) and 20 patients with HELLP syndrome (study group) were included in the study. Placental inflammatory activity was evaluated by quantifying immunohistochemically the levels of p65/RelA expression of nuclear transcription factor-kappa beta (NF-kB) in paraffin-embedded tissue samples. In addition, ultrastructural changes in placental morphology in HELLP patients were evaluated by transmission electron microscopy (TEM). The serum concentrations of myeloperoxidase (MPO) and C-reactive protein (CRP) were also measured and compared. Results: p65/RelA immunoexpression and serum MPO and CRP levels were significantly higher in patients with HELLP syndrome (p < 0.05). TEM of placenta in the study group revealed severely vacuolized syncytiotrophoblasts, irregular basal lamina and damaged capillary endothelium when compared with the placenta of control subjects. Conclusion: Our results suggest that over-expression of placental NF-kB is correlated with elevation of serum inflammatory markers and placental ultrastructural changes, which may point to an important role of local and systemic inflammatory activation in the pathogenesis of HELLP syndrome.en_US
dc.identifier.doi10.3109/10641955.2013.806538
dc.identifier.endpage291en_US
dc.identifier.issn1064-1955
dc.identifier.issn1525-6065
dc.identifier.issue3en_US
dc.identifier.pmid23905607en_US
dc.identifier.scopus2-s2.0-84881192758en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage281en_US
dc.identifier.urihttps://doi.org/10.3109/10641955.2013.806538
dc.identifier.urihttps://hdl.handle.net/11616/96163
dc.identifier.volume32en_US
dc.identifier.wosWOS:000322595700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofHypertension in Pregnancyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHELLP syndromeen_US
dc.subjectInflammationen_US
dc.subjectNuclear transcription factor-kappa beta (NF-kB)en_US
dc.subjectTransmission electron microscopyen_US
dc.titleNuclear transcription factor-kappa beta-dependent ultrastructural alterations within the placenta and systemic inflammatory activation in pregnant patients with hemolysis, elevated liver functions and low thrombocyte count (HELLP) syndrome: a case-control studyen_US
dc.typeArticleen_US

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