Oxyhemoglobin Dissociation Curve in COVID-19 Patients

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dc.authoridUSTUNDAG, Hilal/0000-0003-3140-0755
dc.authoridHUYUT, Mehmet Tahir/0000-0002-2564-991X
dc.authorwosidUSTUNDAG, Hilal/V-2312-2017
dc.contributor.authorUstundag, Hilal
dc.contributor.authorMertoglu, Cuma
dc.contributor.authorHuyut, Mehmet Tahir
dc.date.accessioned2024-08-04T20:11:42Z
dc.date.available2024-08-04T20:11:42Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Coronavirus disease-2019 (COVID-19) is a disease that can progress with hypoxemia and severe respiratory distress in some patients. The oxyhemoglobin dissociation curve (ODC) is critical to understanding the effects of O2 exchange. This study aimed to evaluate the relationship between the ODC and oxygen-carrying capacity of hemoglobin (Hb) in COVID-19 patients.Materials and Methods: In the study, ODCs were created by examining the data obtained from the arterial blood gas analyses of 686 intensive care unit (ICU) and non-ICU COVID-19 patients retrospectively.Results: It was concluded that patients with COVID-19 and other respiratory distress patients had a slight right-leaning trend in the ODC compared with the standard curve. The P50 value of the ICU group was higher than the other groups (mean: 30.74 mmHg, n=131, p=0.047). While the percentage of oxyhemoglobin (mean: 65.44% vs 69.81%, p=0.015), the amount of glucose (mean: 163.39 mg/dL vs 195.36 mg/dL, p=0.002) and pH (median: 7.38 vs 7.41, p=0.007) in the non-ICU group was higher compared with the control group, the carboxyhemoglobin percentage (mean: 1.66% vs 1.13%, p=0.000), PCO2 (42.02 mmHg vs 39.44 mmHg, p=0.015), potassium (mean: 4.33 mmol/L vs 4.04, p=0.026), and sodium (mean: 138.10 mmol/L vs 135.80 mmol/L, p=0.000) were lower. The methemoglobin percentage of the ICU group was lower (p=0.000) than the other groups.Conclusion: The ODC of COVID-19 and other respiratory distress patients shifts slightly to the right, indicating that patients have partial respiratory difficulties.en_US
dc.identifier.doi10.4274/meandros.galenos.2023.87049
dc.identifier.endpage64en_US
dc.identifier.issn2149-9063
dc.identifier.issue1en_US
dc.identifier.startpage58en_US
dc.identifier.trdizinid1178475en_US
dc.identifier.urihttps://doi.org/10.4274/meandros.galenos.2023.87049
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1178475
dc.identifier.urihttps://hdl.handle.net/11616/92926
dc.identifier.volume24en_US
dc.identifier.wosWOS:000988800000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofMeandros Medical and Dental Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjecthematological parametersen_US
dc.subjectoxygen affinityen_US
dc.subjectSARS-CoV-2en_US
dc.titleOxyhemoglobin Dissociation Curve in COVID-19 Patientsen_US
dc.typeArticleen_US

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