Structural changes in periodontium of rats exposed to a low concentration of hydrogen sulfide for 50 days

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridhocaoğlu, turgay peyami/0000-0002-0281-8928
dc.authoridAydin, Murat/0000-0003-0030-8999
dc.authoridGül, Semir/0000-0002-4668-9603
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidhocaoğlu, turgay peyami/AAM-8349-2021
dc.authorwosidAydin, Murat/HCI-8580-2022
dc.authorwosidGül, Semir/ABI-8244-2020
dc.contributor.authorYeler, Defne Yalcin
dc.contributor.authorHocaoglu, Turgay
dc.contributor.authorKoraltan, Melike
dc.contributor.authorAydin, Murat
dc.contributor.authorGul, Mehmet
dc.contributor.authorGul, Semir
dc.date.accessioned2024-08-04T20:42:33Z
dc.date.available2024-08-04T20:42:33Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the effect of H2S inhalation at a low concentration (at human equivalent dose of pathologic halitosis) on rat periodontium over a long term (50 days). The threshold level of pathologic halitosis perceived by humans at 250 ppb of H2S was converted to rat equivalent concentration (4.15 ppm). Rats in the experimental (H2S) group (n = 8) were exposed to H2S continuously but not the control rats (n = 8). After 50 days, periodontal tissue samples were taken from the mandibular first molar region and examined histopathologically to determine inflammatory cell infiltration (ICI), osteoblastic activities, number of osteoclasts, and resorption lacunae. Sulcular epithelium layer destruction was observed in the H2S group. Frequency of ICI was significantly higher in the H2S group compared to the control group (P < 0.05). The number of osteoclasts were found significantly higher in the H2S group (34.28 +/- 3.28) compared to the control group (8.85 +/- 1.85) (P < 0.05) and the number of resorption lacunae were also higher in the cementum tissue (6.1 +/- 2.4) and alveolar bone (3.8 +/- 1.5) versus their corresponding control groups (1.6 +/- 0.5 and 1.4 +/- 0.5, respectively) (P < 0.05). There were no statistically significant differences between the two groups with regard to osteoblastic activity. H2S inhalation induces inflammatory changes in the periodontium as well as resorption of the alveolar bone and cementum tissue in rats. These histopathologic changes in periodontal tissues support the idea that long-term H2S inhalation may have a destructive effect on periodontal tissues.en_US
dc.identifier.doi10.1177/1721727X16659289
dc.identifier.endpage99en_US
dc.identifier.issn1721-727X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84979702717en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.1177/1721727X16659289
dc.identifier.urihttps://hdl.handle.net/11616/97444
dc.identifier.volume14en_US
dc.identifier.wosWOS:000382484200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofEuropean Journal of Inflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthydrogen sulfideen_US
dc.subjecthalitosisen_US
dc.subjectHowship's lacunaeen_US
dc.subjectperiodontal tissueen_US
dc.titleStructural changes in periodontium of rats exposed to a low concentration of hydrogen sulfide for 50 daysen_US
dc.typeArticleen_US

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