Novel Silver-NHC complexes: Synthesis and anticancer properties

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dc.authoridŞAHİN-BÖLÜKBAŞI, Serap/0000-0003-1057-2558;
dc.authorwosidŞAHİN-BÖLÜKBAŞI, Serap/ABJ-7836-2022
dc.authorwosidŞAHİN, Neslihan/F-6402-2019
dc.contributor.authorSahin-Bolukbasia, Serap
dc.contributor.authorSahin, Neslihan
dc.date.accessioned2024-08-04T20:45:53Z
dc.date.available2024-08-04T20:45:53Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to present the synthesis, characterization and anticancer activities of two novel benzimidazole-based NHC salts (1a-b) and their silver(I) complexes (2a-b) with methylbenzyl and isopropylbenzyl chains. All compounds were prepared using Schlenk techniques in an inert atmosphere. The carbene complexes were prepared with the interaction of carbene precursors and Ag2O. All new compounds were characterized by elemental analysis, LC-MS, FT-IR, H-1 NMR, and C-13 NMR spectroscopic techniques. The anticancer activities of the salts and complexes were determined by cell proliferation analysis using (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on human prostate cancer cells (DU-145) and human breast cancer cells (MCF-7, MDA-MB-231). L-929, mouse adipose tissue fibroblasts were used as model normal cells. The cells were plated at a cell density of 1 x 10(5) cells in 96-well plates and treated with different concentrations (1-20 mu M) of salts and complexes during 24, 48 and 72 h. The MTT assay results indicated that the salts (1a-b) have lower anticancer activity on cancer cells than their silver(I) complexes (2a-b). It was also observed that benzimidazole salts (1a-b) and their Ag-NHC complexes (2a-b) displayed lower anticancer activities on L-929 normal cells than on cancer cells. These results highlight that the anticancer activities of N-heterocyclic carbene-silver complexes vary according to the structure of the silver complex and cell line type. (C) 2019 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research of Turkey (TUBITAK-BIDEB), the National Research Fellowship Programmeen_US
dc.description.sponsorshipThe authors thank the Scientific and Technological Research of Turkey (TUBITAK-BIDEB), the National Research Fellowship Programme for grants to N. S. Anticancer activity studies were done at Sivas Cumhuriyet University Advanced Technology Application and Research Center (CUTAM).en_US
dc.identifier.doi10.1016/j.jorganchem.2019.04.018
dc.identifier.endpage84en_US
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-85064692310en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage78en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2019.04.018
dc.identifier.urihttps://hdl.handle.net/11616/98769
dc.identifier.volume891en_US
dc.identifier.wosWOS:000466789300011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbeneen_US
dc.subjectBenzimidazole-2-ylideneen_US
dc.subjectSilveren_US
dc.subjectProstate canceren_US
dc.subjectBreast canceren_US
dc.subjectAnticancer activityen_US
dc.titleNovel Silver-NHC complexes: Synthesis and anticancer propertiesen_US
dc.typeArticleen_US

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