The Beneficial Effects of Pentoxifylline on Caerulein-Induced Acute Pancreatitis in Rats

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dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridAteş, Burhan/0000-0001-6080-229X;
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidOzturk, Feral/A-2678-2016
dc.contributor.authorGul, Mehmet
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorOzturk, Feral
dc.contributor.authorAtes, Burhan
dc.contributor.authorOtlu, Ali
dc.date.accessioned2024-08-04T20:31:07Z
dc.date.available2024-08-04T20:31:07Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study we aimed to investigate the effect of pentoxifylline on caerulein-induced acute pancreatitis (AP) by detecting oxidative stress markers and performing histopathological examination. Twenty-one adult female Sprague-Dawley rats were divided into three groups as follows: control, caerulein, and caerulein + pentoxifylline groups. Pancreatic tissues of rats from all groups were removed for light and electron microscopic examination and determination of oxidative stress markers. Pancreatic oxidative stress markers were evaluated by the measurements of malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and total glutathione (GSH). Serum amylase and lipase levels were determined spectrophotometrically. The pancreatic damage score was significantly increased (P < 0.005) in the caerulein group, whereas it was decreased (P < 0.05) in the caerulein+ with pentoxifylline group. MDA levels, CAT, SOD, GPx, and GSH activities were significantly altered (P < 0.05, P < 0.005) in the caerulein group and indicated increased oxidative stress. Oxidative stress markers were normalized with pentoxifylline administration. Caerulein administration resulted in significant increase (P < 0.05) in amylase and lipase levels; pentoxifylline reduced the levels of these enzymes. Pentoxifylline is potentially capable of limiting pancreatic damage produced during AP by restoring the fine structure of acinar cells and tissue antioxidant enzyme activities. We concluded that pentoxifylline may have beneficial effects in the treatment of caerulein-induced AP.en_US
dc.description.sponsorshipInonu University [2000/11]en_US
dc.description.sponsorshipSupported by the Research Projects Unit of Inonu University, No. 2000/11.en_US
dc.identifier.doi10.1007/s10620-008-0392-x
dc.identifier.endpage563en_US
dc.identifier.issn0163-2116
dc.identifier.issn1573-2568
dc.identifier.issue3en_US
dc.identifier.pmid18688721en_US
dc.identifier.scopus2-s2.0-59449095049en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage555en_US
dc.identifier.urihttps://doi.org/10.1007/s10620-008-0392-x
dc.identifier.urihttps://hdl.handle.net/11616/94744
dc.identifier.volume54en_US
dc.identifier.wosWOS:000262970400013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofDigestive Diseases and Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute pancreatitisen_US
dc.subjectOxidative stressen_US
dc.subjectPentoxifyllineen_US
dc.subjectMicroscopyen_US
dc.titleThe Beneficial Effects of Pentoxifylline on Caerulein-Induced Acute Pancreatitis in Ratsen_US
dc.typeArticleen_US

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