Protective effect of polyunsaturated phosphatidylcholine pretreatment on stress ulcer formation in rats

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dc.authorwosidGürbüz, Necla/H-8965-2018
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.contributor.authorDemirbilek, S
dc.contributor.authorGürses, I
dc.contributor.authorSezgin, N
dc.contributor.authorKaraman, A
dc.contributor.authorGürbüz, N
dc.date.accessioned2024-08-04T20:13:36Z
dc.date.available2024-08-04T20:13:36Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to investigate whether polyunsaturated phosphatidylcholine. (PPC) pretreatment has any protective effect on gastric mucosal damage induced by cold-restraint stress (CRS) in rats. Methods: Forty swiss albino rats were divided into 3 groups. Group 1 (n = 10) was control, group 2 (n = 15) was stress ulcer, and group 3 (n = 15) was PPC-treated rats with stress ulcer. Stress ulcer was induced by the cold-restraint method for 4 hours at 4degreesC after a starvation period of 72 hours. In the group 3 rats, PPC treatment was started 10 days before stress at a dose of 100 mg/d by oral route. Rats were terminated, stomachs were excised. Macroscopic ulcer index (UI), gastric tissue malondialdehyde (MDA) and superoxide dismutase (SOD) activities, plasma total nitrite, and erythrocyte catalase (CAT) concentrations were assayed. Results: Histopathologic examination showed a stress ulcer index of 0.12 +/- 0.19 mm in the treatment group and 23.6 +/- 8.97 mm in the stress ulcer group (P < .001). Tissue MDA and SOD concentrations were higher in the stress ulcer group than in the treatment group, the differences were statistically significant (P < .001). Plasma NO3- + NO2- levels were higher (P < .005) and CAT levels were lower (P < .001) in the nontreatment group. There were no significant differences with respect to UI, MDA, and SOD levels among the control and treatment groups (P > .05). Conclusions: These results suggest that pretreating rats with PPC inhibits cold-restraint stress-induced gastric mucosal injury and might be useful in preventing stress-induced stomach ulcers. (C) 2004 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpedsurg.2003.09.002
dc.identifier.endpage62en_US
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.issue1en_US
dc.identifier.pmid14694372en_US
dc.identifier.scopus2-s2.0-0346401737en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpedsurg.2003.09.002
dc.identifier.urihttps://hdl.handle.net/11616/93703
dc.identifier.volume39en_US
dc.identifier.wosWOS:000188259600012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectstress ulceren_US
dc.subjectstomachen_US
dc.subjectcold restrainten_US
dc.subjectraten_US
dc.subjectpolyunsaturated phosphaticlylcholineen_US
dc.titleProtective effect of polyunsaturated phosphatidylcholine pretreatment on stress ulcer formation in ratsen_US
dc.typeArticleen_US

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