Changing trends in the etiology of liver transplantation in Turkiye: A multicenter study

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dc.authoridDolu, Süleyman/0000-0002-7496-9493
dc.authoridakarsu, mesut/0000-0001-9217-948X
dc.authoridEren, Fatih/0000-0003-2667-8963
dc.authorwosidDolu, Süleyman/HCJ-0010-2022
dc.authorwosidAdanır, Haydar/A-3229-2017
dc.authorwosidakarsu, mesut/AAV-9472-2021
dc.authorwosidAKYILDIZ, Murat/A-2760-2016
dc.contributor.authorAkarsu, Mesut
dc.contributor.authorDolu, Suleyman
dc.contributor.authorHarputluoglu, Murat
dc.contributor.authorYilmaz, Sezai
dc.contributor.authorAkyildiz, Murat
dc.contributor.authorGencdal, Genco
dc.contributor.authorPolat, Kamil Yalcin
dc.date.accessioned2024-08-04T20:55:02Z
dc.date.available2024-08-04T20:55:02Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and aim: This study aimed to identify the indications for liver transplantation (LT) based on underlying etiology and to characterize the patients who underwent LT. Materials and methods: We conducted a multicenter cross-sectional observational study across 11 tertiary centers in Turkiye from 2010 to 2020. The study included 5,080 adult patients. Results: The mean age of patients was 50.3 +/- 15.2 years, with a predominance of female patients (70%). Chronic viral hepatitis (46%) was the leading etiological factor, with Hepatitis B virus infection at 35%, followed by cryptogenic cirrhosis (24%), Hepatitis C virus infection (8%), and alcohol-related liver disease (ALD) (6%). Post-2015, there was a significant increase in both the number of liver transplants and the proportion of living donor liver transplants (p<0.001). A comparative analysis of patient characteristics before and after 2015 showed a significant decline in viral hepatitis-related LT (p<0.001), whereas fatty liver disease-related LT significantly increased (p<0.001). Conclusion: Chronic viral hepatitis continues to be the primary indication for LT in Turkiye. However, the proportions of non-alcoholic fatty liver disease (NAFLD) and ALD-related LT have seen an upward trend over the years.en_US
dc.identifier.doi10.14744/hf.2023.2023.0010
dc.identifier.endpage6en_US
dc.identifier.issn1307-5888
dc.identifier.issn2757-7392
dc.identifier.issue1en_US
dc.identifier.pmid38283275en_US
dc.identifier.scopus2-s2.0-85183838612en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3en_US
dc.identifier.urihttps://doi.org/10.14744/hf.2023.2023.0010
dc.identifier.urihttps://hdl.handle.net/11616/101791
dc.identifier.volume5en_US
dc.identifier.wosWOS:001163820300009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofHepatology Forumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEtiologyen_US
dc.subjectHBVen_US
dc.subjectNAFLDen_US
dc.subjectliver transplantationen_US
dc.titleChanging trends in the etiology of liver transplantation in Turkiye: A multicenter studyen_US
dc.typeArticleen_US

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