Synthesis of palladium complexes containing benzimidazole core and their catalytic activities in direct C-H functionalization of five-membered heterocyclic bioactive motifs

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dc.authoridTouj, Nedra/0000-0001-6071-4361
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authorwosidMansour, Lamjed/AAD-8613-2019
dc.authorwosidTouj, Nedra/G-6828-2019
dc.authorwosidOZDEMIR, ISMAIL/KVY-3420-2024
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.contributor.authorTouj, Nedra
dc.contributor.authorBensalah, Donia
dc.contributor.authorMansour, Lamjed
dc.contributor.authorSauthier, Mathieu
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorHamdi, Naceur
dc.date.accessioned2024-08-04T20:54:48Z
dc.date.available2024-08-04T20:54:48Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHerein, we reported the synthesis of nine new PEPPSI-Pd(II)-N-heterocyclic carbene (NHC) complexes 3a-h containing benzimidazole core and examined their catalytic activities in the direct arylation of heteroaromatic species with aryl bromides and arylchlorides. Nine new Pd benzimidazole complexes were synthesized and their structures were elucidated by 1H and 13C NMR spectroscopy, FT-IR spectroscopy, and elemental analysis methods. In the 13C NMR spectra, NCHN peaks of Pd(II) complexes were observed between 159.7-161.5 ppm. Further, direct arylation reaction, using KOAc as base and DMAc as solvent under inert conditions, were carried out with the synthesized complexes in the presence of various aryl bromides and chlorides, and 2-acetyl furan, and furfuryl acetate 2-acetylthiophene and N-methylpyrrole-2- carboxaldehyde. Moreover, moderate to hig yields were obtained in the direct arylation of heteroarenes and aryl bromides under 1 mol% catalyst loading at 150 degrees C for 2 h loading conditions. The results showed that electron-donating and electron-withdrawing substituents on the aryl halides might produce coupling products in good yields in the presence of complexes 2a-d. Taken together, our findings are expected to contribute to the synthesis and design of palladium complexes containing benzimidazole core structures.en_US
dc.description.sponsorshipKing Saud University, Riyadh, Saudi Arabia [RSP2023R75]en_US
dc.description.sponsorshipThe authors extended their appreciation to the Researchers Supporting Project number (RSP2023R75) , King Saud University, Riyadh, Saudi Arabia.en_US
dc.identifier.doi10.1016/j.molstruc.2023.136885
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85175478084en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2023.136885
dc.identifier.urihttps://hdl.handle.net/11616/101645
dc.identifier.volume1297en_US
dc.identifier.wosWOS:001108254000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCatalysisen_US
dc.subjectCatalystsen_US
dc.subjectN-heterocyclic carbenecarbineen_US
dc.subjectPEPPSI-type palladium-NHC complexesen_US
dc.subjectDirect arylationen_US
dc.subjectStrucutre analysisen_US
dc.titleSynthesis of palladium complexes containing benzimidazole core and their catalytic activities in direct C-H functionalization of five-membered heterocyclic bioactive motifsen_US
dc.typeArticleen_US

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