Efficacy of melatonin as protectant against oxidative stress and structural changes in liver tissue in pinealectomized rats

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dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorSahna, E
dc.contributor.authorParlakpinar, H
dc.contributor.authorVardi, N
dc.contributor.authorCigremis, Y
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:32:17Z
dc.date.available2024-08-04T20:32:17Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPrevious observations demonstrated that physiological levels of metatonin, the pineal secretory product, are important in protecting against oxidative stress-induced tissue damage. We investigated the effects of pinealectomy and administration of exogenous melatonin on liver tissue in rats. Pinealectomized (Px) and sham-operated (non-Px) rats were used. We evaluated structural changes, reduced glutathione (GSH) levels and matondialdehyde (MDA) levels. Rats were divided into three groups (10 rats in each group): control. (non-Px), Px+vehicle and Px+metatonin (4 mg/kg given daily intraperitoneally for 10 days). Liver GSH levels were significantly tower in Px rats than in the control group. Melatonin administration significantly increased GSH levels (p<0.05). Px caused a significant increase in MDA levels as compared with the control group and metatonin administration to Px rats significantly reduced MDA levels in the liver (p<0.05). Sinusoidal dilatation to a varying degree developed in all Px rats. Severity of mononuclear cell. infiltration and sinusoidal congestion were tower in Px+melatonin group than in the Px group. These findings suggest that a significant increase in oxidative and structural changes occur in rat livers after pinealectomy, which can be diminished by melatonin treatment. (C) 2004 Published by Elsevier GmbH.en_US
dc.identifier.doi10.1016/j.acthis.2004.07.006
dc.identifier.endpage336en_US
dc.identifier.issn0065-1281
dc.identifier.issue5en_US
dc.identifier.pmid15530547en_US
dc.identifier.scopus2-s2.0-7644227060en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage331en_US
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2004.07.006
dc.identifier.urihttps://hdl.handle.net/11616/94974
dc.identifier.volume106en_US
dc.identifier.wosWOS:000225792600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUrban & Fischer Verlagen_US
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmelatoninen_US
dc.subjectpinealectomyen_US
dc.subjectglutathioneen_US
dc.subjectmalondialdehydeen_US
dc.subjectliveren_US
dc.titleEfficacy of melatonin as protectant against oxidative stress and structural changes in liver tissue in pinealectomized ratsen_US
dc.typeArticleen_US

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