Nevirapine mitigates monosodium glutamate induced neurotoxicity and oxidative stress changes in prepubertal mice
| dc.contributor.author | Onaolapo, Adejoke Yetunde | |
| dc.contributor.author | Onaolapo, Olakunle James | |
| dc.date.accessioned | 2022-02-22T11:55:03Z | |
| dc.date.available | 2022-02-22T11:55:03Z | |
| dc.date.issued | 2018 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Aim: We investigated the effects of nevirapine on changes in body weight, lipid peroxidation/antioxidant status, apoptotic markers and neuromorphology following monosodium glutamate-induced neurotoxicity in prepubertal mice. Material and Methods: Eighty male mice which were randomly divided into eight groups of ten mice each (n=10) were used. Mice in each group were administered oral vehicle, monosodium glutamate (MSG) at 2g/kg, or one of three doses of nevirapine (at 7.5, 15 and 30 mg/kg) alone or co-administered with MSG. Vehicle or nevirapine were administered daily for 28 days, while MSG was administered on days 1-7. On day 28, animals were euthanized and blood was collected for estimation of plasma malondialdehyde (MDA) and antioxidant levels; while sections of the cerebrum and hippocampus were either fixed and processed for general histology, or homogenized for the estimation of brain biochemical parameters. Results: Results showed that administration of nevirapine alone (or when co-administered with MSG) was associated with a reduction in weight gain, increase in plasma/brain MDA levels, morphologic/morphometric evidence of dose-related hypercellularity; and varying degrees of neuroprotection, with co-administration. Nitric oxide levels and caspase-3 activity increased only with MSG, while superoxide dismutase activity decreased. Conclusions: In conclusion, subchronic administration of nevirapine was associated with dose-related alterations of the measured parameters; indicating possible neuroprotection and mitigation of MSG neurotoxicity at some of the doses studied. | en_US |
| dc.identifier.citation | Yetunde Onaolapo, A., & James Onaolapo, O. (2021). Nevirapine mitigates monosodium glutamate induced neurotoxicity and oxidative stress changes in prepubertal mice . Annals of Medical Research | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/53816 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Annals of Medical Research | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.title | Nevirapine mitigates monosodium glutamate induced neurotoxicity and oxidative stress changes in prepubertal mice | en_US |
| dc.type | Article | en_US |
