Spectral changes in electrical activity of pylorus due to L-NAME induced hypertrophic pyloric stenosis

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dc.authoridAslan, Mehmet/0000-0001-5710-6592
dc.authoridDogan, Derya Gumus/0000-0003-1587-9639
dc.authoridTağluk, M. Emin/0000-0001-7789-6376
dc.authoridAYDIN, Nasuhi/0000-0003-3145-2432
dc.authorwosidAslan, Mehmet/AEL-7823-2022
dc.authorwosidAydin, Nasuhi E/B-6536-2012
dc.authorwosidDogan, Derya Gumus/ABG-9945-2020
dc.authorwosidTağluk, M. Emin/ABH-1005-2020
dc.authorwosidAYDIN, Nasuhi/O-9043-2016
dc.contributor.authorAslan, M.
dc.contributor.authorCelik, O.
dc.contributor.authorDogan, D. G.
dc.contributor.authorTagluk, M. E.
dc.contributor.authorUlas, M.
dc.contributor.authorAydin, E.
dc.date.accessioned2024-08-04T20:32:41Z
dc.date.available2024-08-04T20:32:41Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: To investigate the relation between hypertrophic pyloric stenosis (HPS) and the changes in the myoelectrical activity of the pyloric and gastric areas. Methods: Three pregnant females, at 14 days of gestation two of which were named as D14n (NOS inhibitor group) and one was named as D14c (control). From the beginning of the study until the end of gestation, rats in D14n group received nitric oxide synthase inhibitor L-NAME for administrating their pups, and the rat in D14c group was drinking water for 21 days. The pups of each group underwent laparotomy at 42 days of their life and myoelectrical signals of their pyloric and gastric regions were recorded via bipolar electrodes and then evaluated through signal processing. Results: Signal analysis showed that HPS induced pyloric segment reveals a suppressed spectral component that was detected in normal pyloric segment. The HPS induced pyloric segment also revealed higher power/min and +/- SD compared to that of normal and gastric areas. In the pyloric segment, while the number of interstitial cells of Cajal (ICC) was lesser, the number of smooth muscle cells was higher than in the pyloric segment of controls. Conclusions: The spectral differentials depend on the type, population and condition of locally specialized muscular mechanism which can be affected from HPS. The HPS also has a relation to specific cells, such as ICC that generates NO, provoke the spontaneous pacemakers and biological slow waves (Tab. 1, Fig. 1, Ref. 19). Full Text in free PDF www.bmj.sk.en_US
dc.identifier.endpage17en_US
dc.identifier.issn0006-9248
dc.identifier.issue1en_US
dc.identifier.pmid21452773en_US
dc.identifier.scopus2-s2.0-78751615062en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://hdl.handle.net/11616/95236
dc.identifier.volume112en_US
dc.identifier.wosWOS:000286919700004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpyloric stenosisen_US
dc.subjectL-NAMEen_US
dc.subjectCajall cellsen_US
dc.subjectmyoelectrical activityen_US
dc.titleSpectral changes in electrical activity of pylorus due to L-NAME induced hypertrophic pyloric stenosisen_US
dc.typeArticleen_US

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