Dexpanthenol prevents ovarian ischemic damage via antioxidant mechanisms in rats

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dc.contributor.authorVardi, Nigar
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorCoskun, Ebru Incı
dc.contributor.authorPolat, Seyhan
dc.contributor.authorYıldız, Azibe
dc.contributor.authorOzhan, Onural
dc.date.accessioned2026-04-04T13:14:36Z
dc.date.available2026-04-04T13:14:36Z
dc.date.issued2023
dc.departmentİnönü Üniversitesi
dc.description.abstractOvarian torsion is a gynecological emergency characterized by ovarian ischemic damage. This study aimed to investigate the possible protective effects of dexpanthenol (DEX)-an antioxidant molecule-against ovarian ischemic damage in rats. The rats were simple randomly grouped into (1) Sham group (n=8); (2) Ischemia (I) group (n=8) (2 hours of I in ovaries); (3) DEX+I group (n=8) (500 mg/kg DEX administration 30 minutes before 2 hours of I.) The removed ovaries were examined histopathologically and biochemically. In the DEX+I group, necrosis-pycnosis severity was significantly reduced compared to the I group; but congestion-hemorrhage severity was similar. In the I group, malondialdehyde (MDA) and total oxidant status (TOS) levels were slightly increased, and glutathione (GSH) levels were significantly decreased compared to the Sham group. In the DEX+I group, MDA and TOS levels were slightly reduced and GSH levels were slightly increased compared to the I group. DEX prevents ischemic damage in rat ovaries via an antioxidant effect. Further research is needed to support our findings.
dc.identifier.doi10.5455/medscience.2023.09.184
dc.identifier.endpage1217
dc.identifier.issn2147-0634
dc.identifier.issue4
dc.identifier.startpage1213
dc.identifier.trdizinid1261418
dc.identifier.urihttps://doi.org/10.5455/medscience.2023.09.184
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1261418
dc.identifier.urihttps://hdl.handle.net/11616/107331
dc.identifier.volume12
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMedicine Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250329
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectBiyoteknoloji ve Uygulamalı Mikrobiyoloji
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.titleDexpanthenol prevents ovarian ischemic damage via antioxidant mechanisms in rats
dc.typeArticle

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