Antimicrobial susceptibility pattern of Escherichia coli andKlebsiella pneumoniae isolated from patients with urinarytract infections in a tertiary care hospital

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dc.contributor.authorDoğan, Ahmet
dc.contributor.authorKöse, Adem
dc.contributor.authorGezer, Yakup
dc.contributor.authorErsoy, Yasemin
dc.contributor.authorBayindir, Yasar
dc.contributor.authorÖzden, Mehmet
dc.contributor.authorMemisoglu, Funda
dc.contributor.authorAltunisik Toplu, Sibel
dc.date.accessioned2022-12-06T07:27:57Z
dc.date.available2022-12-06T07:27:57Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: To determine etiological microorganisms from urine samples in patients diagnosed with UTI and to detect the antimicrobial susceptibility pattern of Escherichia coli and Klebsiella pneumoniae in a Tertiary Care Hospital.Materials and Methods: A cross-sectional study was conducted using urine culture samples and sensitivity reports collected retrospectively from our laboratory records over a period from Jan 2013 to Dec 2017.Results: A total of 729 urine culture isolates from 660 patients were included. Two-hundred eighty-four (41.8%) of the patients were male and 384 (58.2%) were female. The most common microorganisms were 46.4% E. coli, 18.2% K. pneumoniae and 12.1% Enterococcus spp., respectively. A total of 284 urine culture isolates produced extended spectrum beta-lactamases (ESBL), of which 186 (65.5%) were E. coli and 98 (34.5%) were K. pneumoniae. The most susceptible antimicrobials are meropenem, imipenem, amikacin, and fosfomycin, respectively. We determined that the antimicrobial drugs with the lowest susceptibility rates for both E. coli and K. pneumoniae were amoxicillin-clavulanate (24.5%), trimethoprim-sulfamethoxazole (30.7%) and ceftriaxone (43.2%). Additionally, their susceptibilities have gradually decreased. Ertapenem susceptibility has decreased more in K. pneumoniae isolates than E. coli.Conclusion: Antimicrobial resistance and ESBL-producing for both E. coli and K. pneumoniae have been increasing over the years. Our findings may contribute to choosing the proper antibiotic for the empirical treatment of UTI and preventing treatment failure.en_US
dc.identifier.citationDOĞAN A, KÖSE A, GEZER Y, ERSOY Y, BAYINDIR Y, ÖZDEN M, MEMİŞOĞLU F, TOPLU S (2021). Antimicrobial susceptibility pattern of Escherichia coli andKlebsiella pneumoniae isolated from patients with urinarytract infections in a tertiary care hospital. Annals of Medical Research, 28(7), 1406 - 1410. 10.5455/annalsmedres.2021.02.172en_US
dc.identifier.doi10.5455/annalsmedres.2021.02.172en_US
dc.identifier.endpage1410en_US
dc.identifier.issn2636-7688
dc.identifier.issue7en_US
dc.identifier.startpage1406en_US
dc.identifier.trdizinid458442en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2021.02.172
dc.identifier.urihttps://hdl.handle.net/11616/85600
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/458442
dc.identifier.volume28en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAntimicrobial susceptibility pattern of Escherichia coli andKlebsiella pneumoniae isolated from patients with urinarytract infections in a tertiary care hospitalen_US
dc.typeArticleen_US

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