The ultrastructural and biochemical evidences of the beneficial effects of chronic caffeic acid phenethyl ester and melatonin administration on brain and cerebellum of aged rats

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dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridYılmaz, İsmet/0000-0002-7204-1050
dc.authoridAteş, Burhan/0000-0001-6080-229X;
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorGul, Mehmet
dc.contributor.authorAtes, Burhan
dc.contributor.authorYilmaz, Ismet
dc.date.accessioned2024-08-04T20:32:23Z
dc.date.available2024-08-04T20:32:23Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNervous system is highly vulnerable to the deleterious effects of age-related oxidative stress. A large body of researches has consistently confirmed the implication of free radicals both in normal cerebral ageing and ageing-related pathologies. In the present study, in addition to the light and electron microscopic pictures of brain and cerebellum of young, old and antioxidant administered old Sprague-Dawley rats, pro-oxidant status was evaluated in terms of measurements of total glutathione, lipid peroxidation (malondialdehyde) and activities of superoxide dismutase, catalase and glutathione peroxidase. Taking the results together, we suggest that supplemental administration of caffeic acid phenethyl ester and melatonin is beneficial in delaying age-related cellular damage in nervous system.en_US
dc.identifier.doi10.1111/j.1472-8206.2009.00782.x
dc.identifier.endpage315en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue3en_US
dc.identifier.pmid19817869en_US
dc.identifier.scopus2-s2.0-77952572875en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage305en_US
dc.identifier.urihttps://doi.org/10.1111/j.1472-8206.2009.00782.x
dc.identifier.urihttps://hdl.handle.net/11616/95037
dc.identifier.volume24en_US
dc.identifier.wosWOS:000277692700005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectageingen_US
dc.subjectbrainen_US
dc.subjectCAPEen_US
dc.subjectcerebellumen_US
dc.subjectmelatoninen_US
dc.titleThe ultrastructural and biochemical evidences of the beneficial effects of chronic caffeic acid phenethyl ester and melatonin administration on brain and cerebellum of aged ratsen_US
dc.typeArticleen_US

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