Effects of Potentilla fulgens as a Prophylactic Agent in Tibial Defects in Rats

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dc.authoridSeker, Ugur/0000-0002-1693-6378;
dc.authorwosidSeker, Ugur/A-7403-2014
dc.authorwosidalan, hilal/ABH-9301-2020
dc.contributor.authorKoparal, Mahmut
dc.contributor.authorIrtegun, Sevgi
dc.contributor.authorAlan, Hilal
dc.contributor.authorDeveci, Engin
dc.contributor.authorGulsun, Belgin
dc.contributor.authorSeker, Ugur
dc.date.accessioned2024-08-04T20:41:39Z
dc.date.available2024-08-04T20:41:39Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the effects of Potentilla fulgens as a prophylactic agent on tibial defects in the rat. STUDY DESIGN: Twenty-eight male Wistar albino rats weighing 200-215 g each were divided into 3 experimental groups. The tibial bone defect group served as the control group. The experimental groups were Potentilla fulgens with tibial defect (14 days) and Potentilla fulgens with tibial defect (28 days). Extract of Potentilla fulgens was mixed with water (400 mg/kg/day) and given to groups 14 and 28 as drinking water. The histopathological and immunohistochemical characteristics of each tibial bone cavity within each group were observed. The trabecular new bone formation was evaluated by expression rate of osteonectin and osteopontin. RESULTS: In the Potentilla fulgens + tibial defect group (14 days), trabecular bone had started combining extensive new bone formation, osteocyte cells were evident, and lamellar bone was formed. Osteoblasts showed a positive reaction with osteonectin. Osteopontin expression was positively observed between fibrous structures and in the osteoblast and osteocyte cells. This can be considered indicative of new bone formation. In the Potentilla fulgens + tibial defect group (28 days), an increase in expansion in trabecular bone and myeloid tissue was observed. Osteoblastic activity and osteocyte cells began to be observed in new bone fragments. CONCLUSION: In our study we show that Potentilla fulgens extract provided a protective effect on new bone formation and aided in the development of osteocytes and secretion of matrix in osteoblasts. Additionally, we show the inductive effect of the extract on new bone formation. In particular, the expression of osteopontin and osteonectin was also supported with the Western blot technique on the development of osteoblasts and osteocytes, showing a similar trend with our results.en_US
dc.identifier.endpage116en_US
dc.identifier.issn0884-6812
dc.identifier.issue2en_US
dc.identifier.pmid27386632en_US
dc.identifier.scopus2-s2.0-84963699481en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://hdl.handle.net/11616/97266
dc.identifier.volume38en_US
dc.identifier.wosWOS:000381062200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbasement membrane tumor proteinen_US
dc.subjectboneen_US
dc.subjectbone tissueen_US
dc.subjectosteoblastsen_US
dc.subjectosteoclastsen_US
dc.subjectosteonectinen_US
dc.subjectosteopontinen_US
dc.subjectPotentilla fulgensen_US
dc.subjectraten_US
dc.subjectrosaceaeen_US
dc.subjecttibialen_US
dc.subjecttibial defecten_US
dc.titleEffects of Potentilla fulgens as a Prophylactic Agent in Tibial Defects in Ratsen_US
dc.typeArticleen_US

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