Comparison of the protective effects of selective endothelin-a receptor antagonist, ambrisentan, and dual endothelin-A/B receptor antagonist, bosentan, in experimental renal ischemia reperfusion injury

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dc.authoridUyumlu, Ayşe Burçin/0000-0001-9517-9274
dc.authoridkaradağ, mehmet/0000-0001-9539-4193
dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authoridPETEKKAYA, EMINE/0000-0002-5366-2425
dc.authorwosidKazımoğlu, Hatem/JFK-9795-2023
dc.authorwosidUyumlu, Ayşe Burçin/ABH-5573-2020
dc.authorwosidkaradağ, mehmet/AFE-8117-2022
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.authorwosidPETEKKAYA, EMINE/KDO-7549-2024
dc.authorwosidPETEKKAYA, EMINE/E-7934-2018
dc.contributor.authorKazimoglu, H.
dc.contributor.authorUysal, E.
dc.contributor.authorDokur, M.
dc.contributor.authorGurer, A. O.
dc.contributor.authorBatcioglu, K.
dc.contributor.authorUyumlu, B. A.
dc.contributor.authorPetekkaya, E.
dc.date.accessioned2024-08-04T20:48:45Z
dc.date.available2024-08-04T20:48:45Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAIM: This study aims to compare the protective effects of ambrisentan, a selective endothelin typeA receptor antagonist, and bosentan, a dual endothelin typeA/B receptor antagonist, on experimental renal ischemia reperfusion injury. METHOD: The study sample consisted of 21 female rats, which were divided into 3 groups: Control, Ambrisentan and Bosentan. For the ischemia-reperfusion injury model, left-kidney nephrectomy was performed after sacrificing the animals. In the immunohistochemical examination, caspase-3 was examined, and then the apoptotic index was determined. In the biochemical examination, the activities of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase, and the levels of nitrite (NOx), TNF-alpha, and IL-1 beta were determined. RESULTS: There were statistically significant differences between the groups in terms of total injury score grade in range of 0.3 (p=0.001).The glomerular and tubular apoptotic indices were higher in the control group as compared to those of the ambrisentan and bosentan groups (p=0.001).There were no statistically significant differences in terms of SOD, CAT, GPx, MDA, IL-1 beta and TNF-alpha measurements among the groups (p>0.05). CONCLUSIONS: In the experimentally created renal ischemia reperfusion model, both ambrisentan and bosentan increased the NOx level, decreased the apoptosis, and protected the kidney from renal ischemia reperfusion injury. However, no significant superiority was found between ambrisentan and bosentan in terms of their protective effects (Tab. 3, Fig. 2, Ref. 31). Text in PDF www.elis.sken_US
dc.identifier.doi10.4149/BLL_2020_091
dc.identifier.endpage553en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue8en_US
dc.identifier.pmid32726116en_US
dc.identifier.scopus2-s2.0-85088828543en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage547en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2020_091
dc.identifier.urihttps://hdl.handle.net/11616/99434
dc.identifier.volume121en_US
dc.identifier.wosWOS:000571574800005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectkidneyen_US
dc.subjectischemia-reperfusionen_US
dc.subjectapoptosisen_US
dc.subjectambrisentanen_US
dc.subjectbosentanen_US
dc.subjectraten_US
dc.titleComparison of the protective effects of selective endothelin-a receptor antagonist, ambrisentan, and dual endothelin-A/B receptor antagonist, bosentan, in experimental renal ischemia reperfusion injuryen_US
dc.typeArticleen_US

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