Microstructural White Matter Alterations in Pediatric Idiopathic Intracranial Hypertension: A Diffusion Tensor Imaging Study

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dc.contributor.authorOzgor, Bilge
dc.contributor.authorAyvaz, Huseyin
dc.contributor.authorTan, Mahir
dc.contributor.authorDemiroz Tasolar, Sevgi
dc.contributor.authorYucel, Gul
dc.contributor.authorBicakcioglu, Isinsu
dc.contributor.authorGungor, Serdal
dc.date.accessioned2026-04-04T13:31:10Z
dc.date.available2026-04-04T13:31:10Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractHighlights What are the main findings? Fractional anisotropy values in the optic radiation and posterior limb of the internal capsule were significantly reduced in pediatric idiopathic intracranial hypertension, indicating microstructural white matter alterations detectable by diffusion tensor imaging. DTI metrics-particularly FA-demonstrated strong discriminative accuracy (AUC = 0.83) for distinguishing affected patients from healthy controls, outperforming conventional MRI markers. What are the implications of the main findings? DTI may serve as a complementary tool to conventional MRI in the diagnostic evaluation of pediatric IIH, providing quantitative insights into pressure-related white matter changes. These findings suggest that advanced diffusion imaging could aid early detection and monitoring of intracranial pressure-related alterations, warranting validation in larger, prospective pediatric cohorts.Highlights What are the main findings? Fractional anisotropy values in the optic radiation and posterior limb of the internal capsule were significantly reduced in pediatric idiopathic intracranial hypertension, indicating microstructural white matter alterations detectable by diffusion tensor imaging. DTI metrics-particularly FA-demonstrated strong discriminative accuracy (AUC = 0.83) for distinguishing affected patients from healthy controls, outperforming conventional MRI markers. What are the implications of the main findings? DTI may serve as a complementary tool to conventional MRI in the diagnostic evaluation of pediatric IIH, providing quantitative insights into pressure-related white matter changes. These findings suggest that advanced diffusion imaging could aid early detection and monitoring of intracranial pressure-related alterations, warranting validation in larger, prospective pediatric cohorts.Abstract Background/Objectives: Idiopathic intracranial hypertension (IIH) is an uncommon but clinically important cause of elevated intracranial pressure in children. Conventional MRI findings such as perioptic subarachnoid space (SAS) distension and posterior globe flattening are helpful but may lack sensitivity or specificity in certain cases. Diffusion tensor imaging (DTI), which quantifies white matter microstructure through metrics such as fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD), offers additional diagnostic potential, yet its role in pediatric IIH remains insufficiently defined. Methods: This retrospective case-control study included 26 pediatric patients with IIH and 26 age- and sex-matched controls who underwent brain MRI with DTI between 2010 and 2025. DTI parameters were measured in major white matter tracts, and conventional MRI findings associated with raised intracranial pressure were recorded. Associations between DTI metrics and conventional imaging markers were analyzed using standardized statistical tests. Results: Children with IIH demonstrated significantly reduced FA and increased MD and RD values in several key white matter regions, particularly within the optic radiation, splenium of the corpus callosum, and posterior limb of the internal capsule. FA values showed a negative correlation with perioptic SAS width, while RD and MD were positively correlated with posterior globe flattening and empty sella grade. Receiver operating characteristic analysis identified FA in the optic radiation as the strongest discriminator between IIH and controls (AUC = 0.83). Inter-observer reliability for FA measurements was excellent (ICC = 0.91). Conclusions: Pediatric IIH appears to be associated with pressure-related microstructural alterations in white matter, detectable through DTI. Among the diffusion metrics, FA demonstrated the strongest diagnostic potential and may serve as a complementary tool to conventional MRI. Validation in larger, prospective pediatric cohorts is required to establish its clinical utility.
dc.identifier.doi10.3390/children12121704
dc.identifier.issn2227-9067
dc.identifier.issue12
dc.identifier.orcid0000-0003-0267-3295
dc.identifier.orcid0000-0002-6697-7629
dc.identifier.pmid41462844
dc.identifier.scopus2-s2.0-105025955511
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/children12121704
dc.identifier.urihttps://hdl.handle.net/11616/108629
dc.identifier.volume12
dc.identifier.wosWOS:001646234400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofChildren-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectidiopathic intracranial hypertension
dc.subjectdiffusion tensor imaging
dc.subjectfractional anisotropy
dc.subjectpediatric MRI
dc.subjectwhite matter
dc.titleMicrostructural White Matter Alterations in Pediatric Idiopathic Intracranial Hypertension: A Diffusion Tensor Imaging Study
dc.typeArticle

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