Important interaction between urethral taste bud-like structures and Onuf's nucleus following spinal subarachnoid hemorrhage: A hypothesis for the mechanism of dysorgasmia

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dc.authoridCaglar, Ozgur/0000-0003-4000-4308
dc.authorwosidCaglar, Ozgur/HQZ-3742-2023
dc.contributor.authorCaglar, Ozgur
dc.contributor.authorAydin, Mehmet Dumlu
dc.contributor.authorAydin, Nazan
dc.contributor.authorAhiskalioglu, Ali
dc.contributor.authorKanat, Ayhan
dc.contributor.authorAslan, Remzi
dc.contributor.authorOnder, Arif
dc.date.accessioned2024-08-04T20:49:16Z
dc.date.available2024-08-04T20:49:16Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: We previously postulated that orgasmic sensation may occur through recently discovered genital taste bud-like structures. The interaction between the pudendal nerve and Onuf's nucleus may be important for developing orgasmic information. The study aims to investigate whether ischemic damage to Onuf's nucleus-pudendal network following spinal subarachnoid hemorrhage (SAH) causes taste bud degeneration or not. Methods: The study was conducted on 22 fertile male rabbits who were divided into three groups: control (GI; n = 5), SHAM (GII; n = 5) and study (GIII; n = 12). Isotonic solution, .7 cm(3), for the SHAM, and .7 cm(3) homologous blood was injected into spinal subarachnoid spaces at S2 level of the study group. Two weeks later, Onuf's nucleus, pudendal ganglia and the taste bud-like structures of the penile urethra were examined histopathologically. Degenerated neuron densities of Onuf's nucleus, pudendal ganglia and atrophic taste bud-like structures were estimated per mm(3) and the results analyzed statistically. Results: The mean degenerated neuron densities of taste bud-like structures, Onuf's nucleusand pudendal ganglia were estimated as 2 +/- 1/mm(3), 5 +/- 1/mm(3), 6 +/- 2/mm(3) in GI; 12 +/- 4/mm(3), 35 +/- 9/mm(3), 188 +/- 31/mm(3), in GII and 41 +/- 8/mm(3), 215 +/- 37/mm(3), 1321 +/- 78/mm(3), in GIII. Spinal SAH induced neurodegeneration in Onuf's nucleus, pudendal ganglia and taste budatrophy was significantly different between GI/GII (p <.005); GII/GIII (p <.0005) and GI/GIII(p<.0001). Conclusion: Ischemic neuronal degenerations of Onuf's nucleus and pudendal ganglia following spinal SAH lead to genital taste bud-like structure atrophy. This mechanism may be responsible for sexual anhedonia and sterility in cases with spinal cord injury, which has not been documented so far. More studies are needed. (C) 2020 Asociacion Espanola de Andrologia, Medicina Sexual y Reproductiva. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.identifier.doi10.1016/j.androl.2020.05.011
dc.identifier.endpage10en_US
dc.identifier.issn1698-031X
dc.identifier.issue1en_US
dc.identifier.pmid33558170en_US
dc.identifier.scopus2-s2.0-85100624693en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.androl.2020.05.011
dc.identifier.urihttps://hdl.handle.net/11616/99758
dc.identifier.volume20en_US
dc.identifier.wosWOS:000742366000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Espana Sluen_US
dc.relation.ispartofRevista Internacional De Andrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUrethral taste budsen_US
dc.subjectSubarachnoid haemorrhageen_US
dc.subjectAnorgasmiaen_US
dc.titleImportant interaction between urethral taste bud-like structures and Onuf's nucleus following spinal subarachnoid hemorrhage: A hypothesis for the mechanism of dysorgasmiaen_US
dc.typeArticleen_US

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