The combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in mice

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dc.authoridKaya Tektemur, Nalan/0000-0001-8880-4932
dc.authoridERDEM GUZEL, ELIF/0000-0002-2097-7818
dc.authorwosidERDEM GÜZEL, ELİF/AAA-5784-2022
dc.authorwosidTektemur, Ahmet/V-8755-2018
dc.authorwosidERDEM GUZEL, ELIF/N-1933-2018
dc.contributor.authorKaya Tektemur, Nalan
dc.contributor.authorErdem Guzel, Elif
dc.contributor.authorGul, Mehmet
dc.contributor.authorTektemur, Ahmet
dc.contributor.authorOzcan Yildirim, Sena
dc.contributor.authorKavak Balgetir, Merve
dc.contributor.authorOzan Kocamuftuoglu, Gonca
dc.date.accessioned2024-08-04T20:49:16Z
dc.date.available2024-08-04T20:49:16Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAcetaminophen (APAP)-induced hepatotoxicity is the most common cause of acute liver failure in worldwide. N-acetyl cysteine (NAC) is used as the APAP antidote. Cyclosporin A (CsA) is suppressed mitochondrial damage by binding cyclophilin, a mitochondrial pore transport component. The study aimed to evaluate the effects of NAC, CsA, and NAC+CsA treatments on APAP-induced hepatotoxicity in mice. Mice were randomly divided into five groups (n = 6). 400 mg/kg/ip/single dose APAP, 1200 mg/kg/i.p/single dose NAC and 50 mg/kg/i.p/single dose CsA were performed. Light and electron microscopic alterations were investigated in liver samples. Levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and liver glutathione (GSH) were analyzed. 3-nitrotyrosine and cytochrome c immunoreactivities were evaluated in liver tissue. Here, we found that APAP leads to histopathological and ultrastructural changes in mice liver. Also, APAP increased cytochrome c and 3-nitrotyrosine immunopositive staining. Besides, a significant decrease in liver GSH and an increase in serum AST and ALT levels were detected in the APAP group. Interestingly, NAC+CsA treatment improved histological alterations, cytochrome c, and 3-nitrotyrosine immunoreactivities and liver GSH, serum AST/ALT levels caused by APAP. We suggest that the combination of NAC and CsA reduces acetaminophen-induced hepatotoxicity in mice.en_US
dc.description.sponsorshipFirat University Scientific Research Projects [TF.18.59]en_US
dc.description.sponsorshipThis study was supported by Firat University Scientific Research Projects(Project No: TF.18.59)en_US
dc.identifier.doi10.1080/01913123.2020.1850964
dc.identifier.endpage27en_US
dc.identifier.issn0191-3123
dc.identifier.issn1521-0758
dc.identifier.issue1en_US
dc.identifier.pmid33530839en_US
dc.identifier.scopus2-s2.0-85100600834en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://doi.org/10.1080/01913123.2020.1850964
dc.identifier.urihttps://hdl.handle.net/11616/99756
dc.identifier.volume45en_US
dc.identifier.wosWOS:000614204400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofUltrastructural Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-acetylcysteineen_US
dc.subjectcyclosporin Aen_US
dc.subjectacetaminophenen_US
dc.subjecthepatotoxicityen_US
dc.titleThe combination of N-acetylcysteine and cyclosporin A reduces acetaminophen-induced hepatotoxicity in miceen_US
dc.typeArticleen_US

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