The Morphological and Numeral Changes of Goblet Cells in the Jejunum of Ischemia-Reperfusion Applied Rats

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dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authorwosidOzturk, Feral/A-2678-2016
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.contributor.authorDag, Meral
dc.contributor.authorKurus, Meltem
dc.contributor.authorSogutlu, Gokhan
dc.contributor.authorEstegoglu, Mukaddes
dc.contributor.authorOzturk, Feral
dc.contributor.authorYologlu, Saim
dc.contributor.authorOtlu, Ali
dc.date.accessioned2024-08-04T20:32:32Z
dc.date.available2024-08-04T20:32:32Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: In this study, we aimed to investigate the numeric and morphological changes of goblet cells after experimental ischemia and reperfusion damage. Material and Methods: In our study, male Sprague Dawley rats were randomly divided into four groups being eight rats in each group. Groups were: control, sham, ischemia (15 minutes) and ischemia-reperfusion groups (I/R, 15 min. I/15 min.R). After the experiment, all rats were sacrificed and their jejunums were taken out. All the necessary procedures were carried out for morphological evaluation. Results: In the ischemia group, villi morphological changes from splitting up to atrophy, and were shorter; goblet cells were found to show reduction both in number and size. On the other hand, it was found that goblet cells in the crypts showed no change in number but in size. Findings in the I/R group were milder than the ischemia group, but the sizes of villi were found smaller in this group. While the number of goblet cells in the villi was normal, it was decreased in the crypts and the sizes of goblets both in the villi and in the crypts were reduced. Conclusion: We thought that during the ischemia, the number of goblets were decreased since they fall into the lumen. The rest were small because they came from the basis of the crypts; during the I/R procedure, the number of cells turned to normal because of the arrival of the goblets from the crypts to the villi. However, in this way the number in them in the crypts decreased and they looked small due to incomplete maturation.en_US
dc.identifier.doi10.5336/medsci.2008-9838
dc.identifier.endpage961en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-77957051270en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage952en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2008-9838
dc.identifier.urihttps://hdl.handle.net/11616/95139
dc.identifier.volume30en_US
dc.identifier.wosWOS:000281262200018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectReperfusion injuryen_US
dc.subjectischemiaen_US
dc.subjectgoblet cellsen_US
dc.subjectjejunumen_US
dc.titleThe Morphological and Numeral Changes of Goblet Cells in the Jejunum of Ischemia-Reperfusion Applied Ratsen_US
dc.typeArticleen_US

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