Methodological considerations for the development of new treatments for bipolar disorder

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dc.contributor.authorPotter, WZ
dc.contributor.authorOzcan, ME
dc.date.accessioned2024-08-04T20:12:04Z
dc.date.available2024-08-04T20:12:04Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractLithium has been the drug of choice in treating bipolar disorder for 50 years and, therefore, patterns of response associated with its use define what we expect from treatment. Although efforts to establish some other agents as antimanic have been successful, it is difficult to assess their overall efficacy in relation to that of lithium without a better understanding of inclusion/exclusion criteria, subtypes, definitions of remission, relapse and recurrence, and duration of study. All of these factors need to be carefully addressed to identify the most important clinical targets for new drug development. Additional relevant information emerges from studies on combinations of mood stabilisers, efficacy of antimanic agents in different patient populations, analysis of rates of drop-out, non-compliance, suicide, drug abuse, and discontinuation especially with long-term treatment. Agents other than lithium that are effective in the acute phase treatment are still not well characterised as mood stabilisers. New agents need to be evaluated in the context of long-term treatment and the targeting of specific components of the syndrome beyond mania.en_US
dc.identifier.doi10.1111/j.1440-1614.1999.00671.x
dc.identifier.endpageS98en_US
dc.identifier.issn0004-8674
dc.identifier.pmid10622183en_US
dc.identifier.scopus2-s2.0-0033390727en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageS84en_US
dc.identifier.urihttps://doi.org/10.1111/j.1440-1614.1999.00671.x
dc.identifier.urihttps://hdl.handle.net/11616/93195
dc.identifier.volume33en_US
dc.identifier.wosWOS:000084437300013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Science Asiaen_US
dc.relation.ispartofAustralian and New Zealand Journal of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbipolar disorderen_US
dc.subjectclinical targeten_US
dc.subjectlithiumen_US
dc.subjectmethodologyen_US
dc.subjectmood stabilisersen_US
dc.titleMethodological considerations for the development of new treatments for bipolar disorderen_US
dc.typeArticleen_US

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