Preventive effect of melatonin on bleomycin-induced lung fibrosis in rats

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dc.authoridYAGMURCA, MURAT/0000-0001-9774-8151;
dc.authorwosidErdogan, Hasan/AFN-9249-2022
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidYAGMURCA, MURAT/A-1851-2018
dc.authorwosidYAĞMURCA, Murat/AAH-4496-2019
dc.contributor.authorYildirim, Z
dc.contributor.authorKotuk, M
dc.contributor.authorErdogan, H
dc.contributor.authorIraz, M
dc.contributor.authorYagmurca, M
dc.contributor.authorKuku, I
dc.contributor.authorFadillioglu, E
dc.date.accessioned2024-08-04T20:15:20Z
dc.date.available2024-08-04T20:15:20Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOxidative stress has an important role in the pathogenesis of idiopathic pulmonary fibrosis. Melatonin has direct and indirect free radical-detoxifying activity. The present study investigated whether melatonin treatment attenuates bleomycin-induced lung fibrosis in rats. A group of rats was given one dose of bleomycin while the control animals were given saline. The first dose of melatonin (4 mg/kg/day) was given 2 days before the bleomycin injection. At day 14, fibrotic changes were evaluated using Aschoft's criteria and lung hydroxyproline content. Bleomycin produced a 2.7-fold rise in the fibrosis score that was decreased 65% by melatonin (P < 0.05) and a 1.4-fold increase in hydroxyproline content which was completely prevented by melatonin. Protein carbonyl and thiobarbituric acid reactive substances levels, which were significantly elevated in the bleomycin treated rats, were significantly attenuated by melatonin. Bleomycin administration significantly reduced the activities of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in lung tissue. The reduction in CAT activity was prevented by melatonin but SOD and GSH-Px were not influenced. These results revealed that melatonin may prevent the development of bleomycin-induced lung fibrosis via the repression of protein and lipid peroxidation.en_US
dc.identifier.doi10.1111/j.1600-079X.2005.00272.x
dc.identifier.endpage33en_US
dc.identifier.issn0742-3098
dc.identifier.issn1600-079X
dc.identifier.issue1en_US
dc.identifier.pmid16313495en_US
dc.identifier.scopus2-s2.0-33644904096en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-079X.2005.00272.x
dc.identifier.urihttps://hdl.handle.net/11616/94308
dc.identifier.volume40en_US
dc.identifier.wosWOS:000233530000004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidanten_US
dc.subjectbleomycinen_US
dc.subjectlipid peroxidationen_US
dc.subjectlung fibrosisen_US
dc.subjectmelatoninen_US
dc.subjectprotein carbonylen_US
dc.subjectratsen_US
dc.subjectthiobarbituric acid reactive substancesen_US
dc.titlePreventive effect of melatonin on bleomycin-induced lung fibrosis in ratsen_US
dc.typeArticleen_US

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