The effect of gonadotropin-releasing hormone analog treatment (leuprolide) on body fat distribution in idiopathic central precocious puberty

Basit Öğe Kaydı
dc.authoridFitoz, Suat/0000-0002-0180-0013
dc.authoridAkinci, Aysehan/0000-0001-7267-9444
dc.authorwosidFitoz, Suat/AAI-8009-2020
dc.authorwosidAkinci, Aysehan/AAC-6847-2021
dc.contributor.authorTascilar, Mehmet Emre
dc.contributor.authorBilir, Pelin
dc.contributor.authorAkinci, Aysehan
dc.contributor.authorKose, Kenan
dc.contributor.authorAkcora, Dilek
dc.contributor.authorInceoglu, Deniz
dc.contributor.authorFitoz, Suat Omer
dc.date.accessioned2024-08-04T20:32:51Z
dc.date.available2024-08-04T20:32:51Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractGonadotropin-releasing hormone analog (GnRHa) therapy is used in idiopathic central precocious puberty (ICPP) worldwide. It has also been shown that during this therapy, body mass index (BMI) increases slightly as a side effect. We investigated the side effects of GnRHa treatment in ICPP on body composition and insulin resistance (IR). Twenty girls (7.55 +/- 1.02 y) with ICPP were treated with GnRHa (leuprolide) for an average of 20.83 +/- 4.8 months. Bioelectrical Impedance Analysis (BIA) was used to measure the body's fat balance. Nine patients out of 20 (45%) had significant gain weight. We showed a significant elevation in trunk fat mass compare to baseline values (p<0.01). These nine patients had high homeostasis model assessment (HOMA)-IR and low glucose/insulin (G/I) index. This study showed a slight increase in BMI, moderate increase in total body fat, and exaggerated elevation in trunk fat mass and IR in GnRHa-treated ICPP children.en_US
dc.identifier.endpage33en_US
dc.identifier.issn0041-4301
dc.identifier.issue1en_US
dc.identifier.pmid21534336en_US
dc.identifier.scopus2-s2.0-79958712295en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://hdl.handle.net/11616/95354
dc.identifier.volume53en_US
dc.identifier.wosWOS:000289862600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectleuprolideen_US
dc.subjectprecocious pubertyen_US
dc.subjectobesityen_US
dc.subjectbody fat compositionen_US
dc.subjectbody mass indexen_US
dc.subjecthyperinsulinismen_US
dc.titleThe effect of gonadotropin-releasing hormone analog treatment (leuprolide) on body fat distribution in idiopathic central precocious pubertyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu