Comparison of major lymphocyte subpopulations and recent thymic emigrants in patients with ataxia telangiectasia and age-matched healthy groups

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dc.authoridtopal, erdem/0000-0002-4439-2689
dc.authoridyildiran, alisan/0000-0002-2918-6238
dc.authorwosidtopal, erdem/ABI-7545-2020
dc.authorwosidCeliksoy, Mehmet Halil/A-3889-2015
dc.authorwosidyildiran, alisan/A-6480-2019
dc.contributor.authorCeliksoy, M. H.
dc.contributor.authorTopal, E.
dc.contributor.authorYildiran, A.
dc.date.accessioned2024-08-04T20:41:10Z
dc.date.available2024-08-04T20:41:10Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Ataxia telangiectasia (A-T) is a genetic disorder caused by the homozygous mutation of the A-T mutated gene. It is frequently associated with variable degrees of cellular and humoral immunodeficiency. However, the immune defects in A-T patients are not well characterized. To the best of our knowledge, no studies have focused on the major lymphocyte subpopulations and recent thymic emigrants of A-T patients in comparison with age-matched healthy controls. Methods: Following the European Society for Immunodeficiencies criteria, 17 patients diagnosed with A-The, and 12 age-matched healthy children were assigned to the study. Both patients and healthy controls were grouped as 1-5, 6-10, 11-15, and 15+ years. By using a flow cytometer, major lymphocyte subpopulations and CD4+CD45RA+CD31+ recent thymic emigrants were determined as percentage and absolute cell numbers and compared. Results: No significant differences in all lymphocyte subpopulations were observed between the age groups of A-T patients. Compared to the healthy controls, there was a decrease in T cells, effector memory T4 cells, B cells, naive B cells, naive 14 cells, switched B cells, and recent thymic emigrants and an increase in active 18 cells and non-switched B cells in the percentage and absolute number of some cell populations in the A-T group. Conclusions: This study showed that effector functions in some cell lymphocyte populations were decreased in A-T patients. (C) 2014 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.identifier.doi10.1016/j.aller.2014.06.007
dc.identifier.endpage481en_US
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue5en_US
dc.identifier.pmid25456532en_US
dc.identifier.scopus2-s2.0-84940955315en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage477en_US
dc.identifier.urihttps://doi.org/10.1016/j.aller.2014.06.007
dc.identifier.urihttps://hdl.handle.net/11616/96970
dc.identifier.volume43en_US
dc.identifier.wosWOS:000361503500010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Doyma Slen_US
dc.relation.ispartofAllergologia Et Immunopathologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtaxia-telangiectasiaen_US
dc.subjectCD31en_US
dc.subjectImmunodeficiencyen_US
dc.subjectLymphocyte subpopulationen_US
dc.subjectPECAM-1en_US
dc.subjectRecent thymic emigrantsen_US
dc.titleComparison of major lymphocyte subpopulations and recent thymic emigrants in patients with ataxia telangiectasia and age-matched healthy groupsen_US
dc.typeArticleen_US

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