Tissue xanthine oxidase activity and nitric oxide levels after spinal cord ischemia/reperfusion injury in rabbits

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dc.authorwosidUz, Efkan/B-2943-2016
dc.contributor.authorSahin, S
dc.contributor.authorSögüt, S
dc.contributor.authorÖzyurt, H
dc.contributor.authorUz, E
dc.contributor.authorIlhan, A
dc.contributor.authorAkyol, Ö
dc.date.accessioned2024-08-04T20:13:09Z
dc.date.available2024-08-04T20:13:09Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCaffeic acid phenethyl ester exhibits antioxidant properties. This experimental study was designed to determine the effect of CAPE on nitric NO level and XO activity after reperfusion injury of spinal cord. New Zealand white rabbits were undergone aortic occlusion. CAPE, methylprednisolone or saline were injected intraperitoneally before surgical intervention. Animals were subjected to 21 min of crossclamp time. At the end of occlusion time, the clamps were removed and restoration of the blood flow was verified visually. Animals in sham group underwent a surgical procedure similar to the other groups but the aorta was not occluded. Spinal cord specimens were obtained to determine the tissue levels of NO and XO activity. Both XO activity and NO level in ischemia group were significantly higher than those of sham group (p = 0.0005 and 0.0003, respectively). MP and CAPE had no effect on XO activity after reperfusion. These two agents decreased NO levels nearly to that of sham group after reperfusion. There were no differences between MP and CAPE on reducing NO level. These results suggest that rabbits with ischemia-reperfusion injury in spinal cord have increased cord concentrations of nitrite and nitrate that are indicative of endogenous overproduction of NO. CAPE may be regarded as an agent that protects spinal cord from ischemia-reperfusion injury.en_US
dc.identifier.doi10.1002/nrc.10044
dc.identifier.endpage121en_US
dc.identifier.issn0893-6609
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0036754649en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://doi.org/10.1002/nrc.10044
dc.identifier.urihttps://hdl.handle.net/11616/93438
dc.identifier.volume31en_US
dc.identifier.wosWOS:000178925700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofNeuroscience Research Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectmethylprednisoloneen_US
dc.subjectspinal corden_US
dc.subjectreperfusion injuryen_US
dc.subjectxanthine oxidaseen_US
dc.subjectnitric oxideen_US
dc.titleTissue xanthine oxidase activity and nitric oxide levels after spinal cord ischemia/reperfusion injury in rabbitsen_US
dc.typeArticleen_US

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