Effects of 2 different doses of pregabalin on morphine consumption and pain after abdominal hysterectomy a randomized double blind clinical trial
Yükleniyor...
Dosyalar
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Current Therapeutic Research
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Pregabalin has a similar pharmacologic profile to that of its
developmental predecessor gabapentin but has shown greater analgesic activity in
rodent models of neuropathic pain.
Objective: The objective of the study was to compare the effects of 2 different
doses of pregabalin and placebo on postoperative pain and morphine consumption.
Methods: Ninety patients who underwent abdominal hysterectomy were included
in the study and randomly divided into 3 groups in a doubled-blinded
manner. They were given 150 mg of pregabalin (group P300, n 30), 300 mg of
pregabalin (group P600, n 30), or placebo capsules (group C, n 30) 4 hours
before the induction of anesthesia; they received a second dose of the drug 12 hours
postoperatively. Morphine consumption, nausea, and vomiting, visual analogue scalepain
intensity (VAS-PI), sedation scores, and dissatisfaction scores were recorded in
the postanesthesia care unit (PACU) and at 2, 4, 6, and 24 hours after operation.
Results: Morphine consumption at 24 hours was 40.80 (3.42) mg, 33.79
(5.77) mg, and 46.97 (6.67) mg in groups P300, P600, and C, respectively (P
0.001). VAS-PI scores at movement and at rest in the PACU and at 2, 4, and 6 hours
decreased in group P600 (P 0.01). In the PACU and at 2, 4, and 6 hours, the
sedation scores were increased in group P600 compared with the scores in group C
(P 0.001, P 0.001, P 0.01, P 0.006, respectively). Patient satisfaction was
higher in group P600 than in group C for all time points (P 0.001, P 0.001,
P 0.001, P 0.001, P 0.001, respectively). There were no statistically
significant differences between the groups for side effects such as nausea, vomiting,
and dizziness (P 0.58).
Conclusions: Pregabalin at a total dose of 600 mg, administered before
operation and at 12 hours postoperatively after abdominal hysterectomy, reduced
morphine consumption and pain intensity and increased patient satisfaction. No significant differences in side effects were observed between the study groups. (Curr
Ther Res Clin Exp. 2011;72:173-183) © 2011 Elsevier HS Journals, Inc. All rights
reserved.
Açıklama
Anahtar Kelimeler
Morphine consumption, Pain, Postoperative, Pregabalin
Kaynak
Current Therapeutic Research
WoS Q Değeri
Scopus Q Değeri
Cilt
72
Sayı
4
Künye
Yücel, A. Öztürk, E. Aydoğan, M. S. Durmuş, M. Çolak, C. Ersoy, M. Ö. (2011). Effects of 2 different doses of pregabalin on morphine consumption and pain after abdominal hysterectomy a randomized double blind clinical trial. Current Therapeutic Research, 72(4), 173–183.
