Effect of smoking on serum concentrations of total homocysteine, folate, vitamin B12, and nitric oxide in pregnancy

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dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.authorwosidÖzerol, İbrahim Halil/ABI-8015-2020
dc.contributor.authorÖzerol, E
dc.contributor.authorÖzerol, I
dc.contributor.authorGökdeniz, R
dc.contributor.authorTemel, I
dc.contributor.authorAkyol, O
dc.date.accessioned2024-08-04T20:13:40Z
dc.date.available2024-08-04T20:13:40Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Nitric oxide (NO) is a potent vasodilator released by endothelial cells that plays an important role in modulating maternal and fetal vascular tone in normal pregnancy. Lower plasma levels of vitamins may result in hyperhomocysteinemia, a known risk factor in pregnancy. The aim of this study was to investigate whether there are alterations in the serum levels of total homocysteine (tHcy), folate, vitamin B-12, and total nitrite, as an index of NO, in smoking as compared with age-matched nonsmoking pregnant women. Methods: Thirty-three women (19 smoking and 14 nonsmoking) between 16 and 22 weeks of their gestation were included in this study. The serum tHcy levels were analyzed by using an enzyme-linked immunosorbent assay kit. Vitamin B12 and folate values were measured by means of DPC kits. Total nitrite was measured by Griess reaction as an index of endogenous NO production. Results: The serum tHcy concentrations were significantly increased in smoking as compared with nonsmoking pregnant women (p<0.001). The folate and vitamin B-12 concentrations were lower in smoking than in nonsmoking pregnant women, but only the differences in folate concentrations were statistically significant (p<0.001). The tHcy concentrations showed a significant negative correlation with folate in the smoking pregnant women. The serum total nitrite concentrations were lower in smoking than in nonsmoking pregnant women (p<0.05). In addition, the serum nitrite levels in smoking pregnant women had significant negative correlations with tHcy and positive correlations with folate and vitamin B-12 levels. Conclusions: In the light of our findings, we propose that smoking might enhance the vasoconstrictor capacity in pregnant women by increased tHcy concentrations and by a simultaneous decrease in the production of NO which is a vasodilator compound. Copyright (C) 2004 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000075139
dc.identifier.endpage148en_US
dc.identifier.issn1015-3837
dc.identifier.issue2en_US
dc.identifier.pmid14764959en_US
dc.identifier.scopus2-s2.0-1142286318en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://doi.org/10.1159/000075139
dc.identifier.urihttps://hdl.handle.net/11616/93775
dc.identifier.volume19en_US
dc.identifier.wosWOS:000188751900009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofFetal Diagnosis and Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsmokingen_US
dc.subjecthomocysteineen_US
dc.subjectfolateen_US
dc.subjectvitamin B-12en_US
dc.subjectnitric oxideen_US
dc.subjectpregnancyen_US
dc.titleEffect of smoking on serum concentrations of total homocysteine, folate, vitamin B12, and nitric oxide in pregnancyen_US
dc.typeArticleen_US

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