Role of selenium compounds on tyrosine hydroxylase activity, adrenomedullin and total RNA levels in hearts of rats

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dc.authoridYılmaz, İsmet/0000-0002-7204-1050
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authorwosidYılmaz, ismet/AAG-8946-2019
dc.authorwosidYılmaz, İsmet/P-9976-2015
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorTalas, Zeliha Selamoglu
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorGok, Yetkin
dc.contributor.authorAtes, Burhan
dc.contributor.authorYilmaz, Ismet
dc.date.accessioned2024-08-04T20:32:13Z
dc.date.available2024-08-04T20:32:13Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSynthetic organoselenium compounds can be tailored to achieve greater chemopreventive efficacy with minimal toxic side effects by structural modifications. Two organoselenium compounds (Se I and Se II) were synthesized and evaluated for their antihypertensive and therapeutic properties by adrenomedullin (ADM) levels and tyrosine hydroxylase (TH) activity assays in rat heart tissue. 7,12-Dimethylbenz[a]anthracene (DMBA) is known to generate DNA-reactive species during their metabolism, which may enhance oxidative stress in cells. TH is thought to be a rate-limiting enzyme in the biosynthesis of catecholamines. ADM, a potent endogenous vasodilating and natriuretic peptide, may play an important role in the pathophysiology of chronic heart failure. The effects of Se I and Se II were investigated on TH activity, ADM and total RNA levels in the hearts of albino Wistar rats. TH activity was found to be increased significantly by the effect of DMBA (P < 0.05). This increase was restricted in the Se I and Se H treated groups. ADM level was found to be decreased insignificantly by the effect of DMBA (P > 0.05). Total RNA level was found to be decreased significantly by the effect of DMBA (P < 0.05). This study demonstrates that synthetic organoselenium compounds can regulate DMBA-induced stress related changes in rat heart. (C) 2009 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipInonu University [BAP 2005/60]en_US
dc.description.sponsorshipInonu University Research Fund (BAP 2005/60) is gratefully acknowledged for support of this work.en_US
dc.identifier.doi10.1016/j.regpep.2009.08.009
dc.identifier.endpage141en_US
dc.identifier.issn0167-0115
dc.identifier.issn1873-1686
dc.identifier.issue1-3en_US
dc.identifier.pmid19706312en_US
dc.identifier.scopus2-s2.0-71349085372en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.1016/j.regpep.2009.08.009
dc.identifier.urihttps://hdl.handle.net/11616/94924
dc.identifier.volume159en_US
dc.identifier.wosWOS:000273920500021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofRegulatory Peptidesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTyrosine hydroxylaseen_US
dc.subjectAdrenomedullinen_US
dc.subjectHearten_US
dc.subjectOrganoselenium compoundsen_US
dc.subjectRaten_US
dc.titleRole of selenium compounds on tyrosine hydroxylase activity, adrenomedullin and total RNA levels in hearts of ratsen_US
dc.typeArticleen_US

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