Neuropeptide Y alters stress-induced changes in trace element concentrations of brain in chronically immobilized rats

dc.authorwosidYILDIRIM, EJDER A/M-2681-2013
dc.authorwosidMENGİ, MURAT/Q-7048-2017
dc.contributor.authorKarakoc, Y
dc.contributor.authorTurhan, S
dc.contributor.authorYildirim, EA
dc.contributor.authorMengi, M
dc.contributor.authorYurdakos, E
dc.contributor.authorBarutcu, UB
dc.date.accessioned2024-08-04T20:32:12Z
dc.date.available2024-08-04T20:32:12Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCentral administration of neuropeptide Y (NPY) produces anxiolytic-like behavioral responses in the conflict test, elevated plus maze, fear-potentiated startle paradigm, and in the chronic immobilization stress. Exogenously administrated NPY also protects against the anxiogenic effects of corticotropin-releasing factor. In the present study, we aimed to determine the effects of centrally administered NPY on the trace element disturbances in brain tissues (frontal and temporal lobes and brain stem) and the other major organs including liver, spleen (zinc [Zn]-, copper [Cu]-, and iron-rich tissues), kidney, and stomach in chronically immobilized rats. The immobilization stress was performed in special cages in which the animals were not able to move. The rats in chronic stress and chronic stress + NPY groups were kept in the cages daily for 7 min for 15 consecutive days. Intracerebroventricular (ICV) cannulas were placed to the right lateral ventricles of the rats by using stereotaxic method. In the control and chronic stress groups, 5 muL of saline (NaCl 0.9%), and in the chronic stress + NPY group, 8 mug NPY/5 muL saline solutions, were administered into the brain via ICV cannula, respectively. Controls and immobilized rats were decapitated 30 min after the injections were over and samples of tissue were taken. Zn, Cu, and iron levels of the frontal lobe, temporal lobe, brain stem, liver, spleen, kidney, and stomach were determined by flame atomic absorption spectrophotometer. Zn and Cu levels were significantly increased in the frontal lobe, temporal lobe, and brain stem in response to chronic immobilization stress daily for 7 min for 15 consecutive days. The administration of NPY inhibited the elevation of Zn in these three parts of brain but did not affect the elevation of Cu in the frontal lobe and brain stem. Increases in Zn and Cu levels of frontal, temporal lobes, and brain stem may be related to induction of MT-I mRNA expression by chronic immobilization stress, and NPY may affect this induction of MT-I, altering corticotropin-releasing factor release in the stress conditions.en_US
dc.identifier.doi10.1002/jtra.20011
dc.identifier.endpage290en_US
dc.identifier.issn0896-548X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-7044247733en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage283en_US
dc.identifier.urihttps://doi.org/10.1002/jtra.20011
dc.identifier.urihttps://hdl.handle.net/11616/94903
dc.identifier.volume17en_US
dc.identifier.wosWOS:000224374400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-Lissen_US
dc.relation.ispartofJournal of Trace Elements in Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectimmobilizationen_US
dc.subjectrestraint stressen_US
dc.subjectzincen_US
dc.subjectcopperen_US
dc.subjectironen_US
dc.subjectraten_US
dc.subjectneuropeptide Yen_US
dc.titleNeuropeptide Y alters stress-induced changes in trace element concentrations of brain in chronically immobilized ratsen_US
dc.typeArticleen_US

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