Long-term effects of orchiopexy and orchiectomy on the testes of rats with testicular torsion

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dc.authoridARSLAN, Ahmet Kadir/0000-0001-8626-9542
dc.authoridAKATLI, AYSE NUR/0000-0002-9677-2456
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridTasci, Aytac/0000-0002-4024-5219
dc.authorwosidARSLAN, Ahmet Kadir/AAA-2409-2020
dc.authorwosidAKATLI, AYSE NUR/ABH-4455-2020
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorTasci, Aytac
dc.contributor.authorUguralp, Sema
dc.contributor.authorAkatli, Ayse Nur
dc.contributor.authorArslan, Ahmet Kadir
dc.contributor.authorKarabulut, Aysun Bay
dc.date.accessioned2024-08-04T20:51:57Z
dc.date.available2024-08-04T20:51:57Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction Ischemia/reperfusion injury occurs after testicular torsion, levels of free oxygen radicals and inflammatory cytokines are increased in both the torsional and contralateral testis, leading to testicular injury. Objective The present study investigated whether orchiopexy or orchiectomy after testicular torsion was superior in terms of fertility potential in the long term. Study design Following 720 degrees, 4 h left testicular torsion, orchiectomy or orchiopexy was performed on 84 rats, which were then sacrificed and evaluated for testicular function at day 1, at 3 months and 6 months (n = 14 per group). An additional 14 rats were in the control group. Results Follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels were significantly lower in the orchiopexy group than the orchiectomy and control groups after 3 months. However, there were no significant differences in hormone parameters among the three groups after 6 months. The hormone levels, Johnsen score, seminiferous tubule diameter, and inducible nitric oxide synthase (iNOS) expression at 3 and 6 months were not significantly different between the orchiectomy group and controls. Histopathological analyses at 3 and 6 months indicated significant decreases in Johnsen score and seminiferous tubule diameter in the ipsilateral testis in the orchiopexy group. At 3 months, the level of iNOS expression in the contralateral testis was significantly lower in the orchiopexy group than in other groups. At 6 months, however, it was not significantly different between the orchiopexy and control groups. There were no significant differences in iNOS expression at 3 or 6 months in the orchiectomy group compared to controls. Discussion The ipsilateral testis in the orchiopexy group began to atrophy at 3 months, and the degree of atrophy became more evident at 6 months. The level of iNOS expression was low in the bilateral testis at 3 months in the orchiopexy group, and sperm in the contralateral testis were not yet functionally healthy. The level of iNOS expression in the ipsilateral testis decreased further at 6 months in the orchiopexy group, while that in the contralateral testis returned to the normal level. Conclusion Testicular functions were restored faster after orchiectomy compared to orchiopexy following testicular torsion. However, follow-up of the rats for 6 months demonstrated that orchiopexy or orchiectomy procedures conducted on the testicular torsion had no effect on future fertility potential after 4 h of torsion.en_US
dc.description.sponsorshipInonu University Project Research Unit, Malatya, Turkeyen_US
dc.description.sponsorshipThis research was funded by Inonu University Project Research Unit, Malatya, Turkey.en_US
dc.identifier.doi10.1016/j.jpurol.2022.04.007
dc.identifier.issn1477-5131
dc.identifier.issn1873-4898
dc.identifier.issue3en_US
dc.identifier.pmid35568660en_US
dc.identifier.scopus2-s2.0-85130408629en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpurol.2022.04.007
dc.identifier.urihttps://hdl.handle.net/11616/100662
dc.identifier.volume18en_US
dc.identifier.wosWOS:000911711000012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal of Pediatric Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTesticular torsionen_US
dc.subjectFSHen_US
dc.subjectLHen_US
dc.subjectTestosteronen_US
dc.subjectJohnsen scoreen_US
dc.subjectiNOSen_US
dc.titleLong-term effects of orchiopexy and orchiectomy on the testes of rats with testicular torsionen_US
dc.typeArticleen_US

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