Curcumin protects heart tissue against irinotecan-induced damage in terms of cytokine level alterations, oxidative stress, and histological damage in rats
dc.authorid | basak, nese/0000-0001-5566-8321 | |
dc.authorid | Taşlidere, Aslı Cetin/0000-0003-3902-3210 | |
dc.authorid | Ciftci, Osman/0000-0001-5755-3560 | |
dc.authorwosid | basak, nese/ABH-5495-2020 | |
dc.authorwosid | Taşlıdere, Aslı/ABI-8274-2020 | |
dc.authorwosid | Taşlidere, Aslı Cetin/AAB-3979-2021 | |
dc.contributor.author | Ciftci, Osman | |
dc.contributor.author | Turkmen, Nese Basak | |
dc.contributor.author | Taslidere, Asli | |
dc.date.accessioned | 2024-08-04T20:44:38Z | |
dc.date.available | 2024-08-04T20:44:38Z | |
dc.date.issued | 2018 | |
dc.department | İnönü Üniversitesi | en_US |
dc.description.abstract | Irinotecan (CPT-11), commonly used in the treatment of many cancer types, may have several side effects that limit the use of CPT-11 in specific tissues such as the heart. In the current study, positive effects of curcumin (CRC) was determined in terms of antioxidant and anti-inflammatory properties against heart damage, caused by CPT-11, in rats. Rats were divided randomly into four equal groups (Control, CPT-11, CRC, and CPT-11 + CRC). CPT-11 10 mg/kg/day was administered intraperitoneally and CRC 100 mg/kg(-1) was given orally. Blood and tissue samples were collected from all groups at day 30 for the detection of oxidative stress, histological changes, and cytokine levels. Results showed that CPT-11 caused dramatic changes in heart tissue for oxidative stress parameters (TBARS, SOD, CAT, GSH, and GPx levels), histological tissue damage, and cytokine levels (TNF and IL-4). CRC therapy reversed the elevated oxidative stress, histological tissue damages, and immunological changes and protected cardiac tissue against CPT-11 toxicity when given together with CPT-11. In conclusion, CPT-11 caused adverse effects on cytokine levels, histological alterations, and oxidative stress in rats. However, CRC treatment eliminated these toxic effects with its antioxidant and anti-inflammatory properties. Thus, these results suggest that CRC may play a protective role against CPT-11 toxicity in heart tissue of rats. | en_US |
dc.identifier.doi | 10.1007/s00210-018-1495-3 | |
dc.identifier.endpage | 791 | en_US |
dc.identifier.issn | 0028-1298 | |
dc.identifier.issn | 1432-1912 | |
dc.identifier.issue | 8 | en_US |
dc.identifier.pmid | 29721577 | en_US |
dc.identifier.scopus | 2-s2.0-85049688338 | en_US |
dc.identifier.scopusquality | Q2 | en_US |
dc.identifier.startpage | 783 | en_US |
dc.identifier.uri | https://doi.org/10.1007/s00210-018-1495-3 | |
dc.identifier.uri | https://hdl.handle.net/11616/98374 | |
dc.identifier.volume | 391 | en_US |
dc.identifier.wos | WOS:000437682900002 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.ispartof | Naunyn-Schmiedebergs Archives of Pharmacology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Irinotecan | en_US |
dc.subject | Curcumin | en_US |
dc.subject | Cytokine | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Histological alterations | en_US |
dc.title | Curcumin protects heart tissue against irinotecan-induced damage in terms of cytokine level alterations, oxidative stress, and histological damage in rats | en_US |
dc.type | Article | en_US |