Curcumin protects heart tissue against irinotecan-induced damage in terms of cytokine level alterations, oxidative stress, and histological damage in rats

dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidTaşlıdere, Aslı/ABI-8274-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorCiftci, Osman
dc.contributor.authorTurkmen, Nese Basak
dc.contributor.authorTaslidere, Asli
dc.date.accessioned2024-08-04T20:44:38Z
dc.date.available2024-08-04T20:44:38Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIrinotecan (CPT-11), commonly used in the treatment of many cancer types, may have several side effects that limit the use of CPT-11 in specific tissues such as the heart. In the current study, positive effects of curcumin (CRC) was determined in terms of antioxidant and anti-inflammatory properties against heart damage, caused by CPT-11, in rats. Rats were divided randomly into four equal groups (Control, CPT-11, CRC, and CPT-11 + CRC). CPT-11 10 mg/kg/day was administered intraperitoneally and CRC 100 mg/kg(-1) was given orally. Blood and tissue samples were collected from all groups at day 30 for the detection of oxidative stress, histological changes, and cytokine levels. Results showed that CPT-11 caused dramatic changes in heart tissue for oxidative stress parameters (TBARS, SOD, CAT, GSH, and GPx levels), histological tissue damage, and cytokine levels (TNF and IL-4). CRC therapy reversed the elevated oxidative stress, histological tissue damages, and immunological changes and protected cardiac tissue against CPT-11 toxicity when given together with CPT-11. In conclusion, CPT-11 caused adverse effects on cytokine levels, histological alterations, and oxidative stress in rats. However, CRC treatment eliminated these toxic effects with its antioxidant and anti-inflammatory properties. Thus, these results suggest that CRC may play a protective role against CPT-11 toxicity in heart tissue of rats.en_US
dc.identifier.doi10.1007/s00210-018-1495-3
dc.identifier.endpage791en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue8en_US
dc.identifier.pmid29721577en_US
dc.identifier.scopus2-s2.0-85049688338en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage783en_US
dc.identifier.urihttps://doi.org/10.1007/s00210-018-1495-3
dc.identifier.urihttps://hdl.handle.net/11616/98374
dc.identifier.volume391en_US
dc.identifier.wosWOS:000437682900002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNaunyn-Schmiedebergs Archives of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIrinotecanen_US
dc.subjectCurcuminen_US
dc.subjectCytokineen_US
dc.subjectOxidative stressen_US
dc.subjectHistological alterationsen_US
dc.titleCurcumin protects heart tissue against irinotecan-induced damage in terms of cytokine level alterations, oxidative stress, and histological damage in ratsen_US
dc.typeArticleen_US

Dosyalar