The protective effect of erdosteine against ototoxicity induced by cisplatin in rats

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dc.authoridKIZILAY, Ahmet/0000-0003-3048-6489
dc.authoridOZTURAN, ORHAN/0000-0002-6129-8627
dc.authorwosidKalcioglu, M. Tayyar/JAC-1515-2023
dc.authorwosidKALCIOGLU, Mahmut Tayyar/I-5884-2013
dc.authorwosidOZTURAN, ORHAN/E-9610-2012
dc.authorwosidKIZILAY, Ahmet/ABI-8293-2020
dc.authorwosidOZTURAN, ORHAN/B-4984-2015
dc.contributor.authorKalcioglu, MT
dc.contributor.authorKizilay, A
dc.contributor.authorGulec, M
dc.contributor.authorKaratas, E
dc.contributor.authorIraz, M
dc.contributor.authorAkyol, O
dc.contributor.authorEgri, M
dc.date.accessioned2024-08-04T20:15:04Z
dc.date.available2024-08-04T20:15:04Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe elimination of cisplatin ototoxicity is an ongoing concern. This experimental study was undertaken to investigate the effect of oral erdosteine in ameliorating cisplatin-induced ototoxicity. Twenty-eight adult female Wistar albino rats were randomly divided into four equal groups. Group A received an oral carrier vehicle of the drug erdosteine with 0.2 ml of 0.9% saline. Group B was administered only erdosteine (per oral 10 mg/kg twice a day) for 6 days. Group C was injected with cisplatin intraperitoneally (i.p.) on day 0 (16 mg/kg body weight), once only. Group D was given erdosteine (per oral 10 mg/kg/day) 1 day before and for 5 days consecutively after cisplatin injection (16 mg/kg, i.p.). Distortion product otoacoustic emissions (DPOAEs) were elicited in different frequency regions, ranging from 1,001 to 6,299 Hz as DPgram and input/output (I/O) functions from the control and experimental animals. All experimental animals were killed under general anesthesia on day 5, following the last otoacoustic emission measurements. Prior to death, blood samples were drawn for measurement of superoxide dismutase, xanthine oxidase (XO), malondialdehyde and nitric oxide. Initial DPgram and I/O function baseline measurements were similar in all groups prior to any drug administration ( P > 0.05). On day 5, intra-subject measurement parameters of DPgrams and I/O functions in the cisplatin group showed significant deterioration ( P < 0.05). The other groups revealed no differences between their pre- and post-test drug administration DPgrams and I/O functions at any test frequency ( P > 0.05). Comparison of the amplitudes of DPgrams and I/O functions between the cisplatin and control groups showed significant changes ( P < 0.05). Biochemical studies noted an increased XO activity following cisplatin administration ( P < 0.007). The other biochemical results did not show significant differences between the study and control groups. This study demonstrates that, in rats, erdosteine is protective for cochlear function against the disruptive effects of cisplatin as measured by DPOAEs.en_US
dc.identifier.doi10.1007/s00405-004-0909-7
dc.identifier.endpage863en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue10en_US
dc.identifier.pmid15742177en_US
dc.identifier.scopus2-s2.0-27744486752en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage856en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-004-0909-7
dc.identifier.urihttps://hdl.handle.net/11616/94159
dc.identifier.volume262en_US
dc.identifier.wosWOS:000233102100014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectototoxicityen_US
dc.subjectcisplatinen_US
dc.subjectantioxidantsen_US
dc.subjecterdosteineen_US
dc.subjectotoacoustic emissionsen_US
dc.subjectreactive oxygen speciesen_US
dc.subjectxanthine oxidaseen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectmalondialdehydeen_US
dc.subjectnitric oxideen_US
dc.titleThe protective effect of erdosteine against ototoxicity induced by cisplatin in ratsen_US
dc.typeArticleen_US

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