Analyses of changes on skin by aging

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dc.authorwosidAtasever, Alper/Q-1150-2018
dc.contributor.authorKazanci, A.
dc.contributor.authorKurus, M.
dc.contributor.authorAtasever, A.
dc.date.accessioned2024-08-04T20:42:31Z
dc.date.available2024-08-04T20:42:31Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: This study aimed to evaluate the histological changes occurring in rat skin with increasing age, starting from the intrauterine period. Methods: Thirty-two healthy female Sprague-Dawley rats were evaluated in four groups: group 1 - intrauterine day 19, group 2 - postpartum day 21, group 3 - postpartum day 60, and group 4 - postpartum month 19. Skin samples from the back, abdomen, head, and upper and lower limbs were obtained from each subject under anesthesia. Tissue specimens were evaluated statistically and morphologically for the thicknesses of the epidermis, dermis, and basement membrane; the number, height, and width of dermal papillae; and the mast cell and pilosebaceous counts per group. The changes in collagen/elastic fibers and glycosaminoglycans were also assessed. Results: Epidermal thickness was the highest in the intrauterine group; it decreased in the postpartum period and increased again in the aged group. Basal membrane thickness increased steadily with age. The number, height, and width of dermal papillae and dermal thickness increased up to day 60 after birth although these decreased in the aged group. Mast cell count also reached the maximum in the intrauterine group and gradually decreased with age. Pilosebaceous units of the dermis were fewer in intrauterine specimens; they showed an increase during the postpartum period and a decrease in the aged group. Conclusion: Skin specimens obtained from rats showed striking differences between the intrauterine and postpartum groups. Moreover, the postpartum group showed considerable intra-group differences.en_US
dc.identifier.doi10.1111/srt.12300
dc.identifier.endpage60en_US
dc.identifier.issn0909-752X
dc.identifier.issn1600-0846
dc.identifier.issue1en_US
dc.identifier.pmid27321201en_US
dc.identifier.scopus2-s2.0-84978301579en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage48en_US
dc.identifier.urihttps://doi.org/10.1111/srt.12300
dc.identifier.urihttps://hdl.handle.net/11616/97411
dc.identifier.volume23en_US
dc.identifier.wosWOS:000393359700007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofSkin Research and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectagingen_US
dc.subjectskinen_US
dc.subjectraten_US
dc.subjectmorphologyen_US
dc.subjectintrauterine skin histologyen_US
dc.subjectepidermal thicknessen_US
dc.subjectmast cellen_US
dc.titleAnalyses of changes on skin by agingen_US
dc.typeArticleen_US

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