Effects of caffeic acid phenethyl ester against doxorubicin-induced neuronal oxidant injury

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dc.authoridYAGMURCA, MURAT/0000-0001-9774-8151;
dc.authorwosidYAGMURCA, MURAT/A-1851-2018
dc.authorwosidYAĞMURCA, Murat/AAH-4496-2019
dc.authorwosidErdogan, Hasan/AFN-9249-2022
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.contributor.authorFadillioglu, E
dc.contributor.authorErdogan, H
dc.contributor.authorIraz, M
dc.contributor.authorYagmurca, M
dc.date.accessioned2024-08-04T20:13:30Z
dc.date.available2024-08-04T20:13:30Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOxygen-derived free radicals have been implicated in the pathogenesis of doxorubicin-induced toxicities. The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE), an antioxidant agent, on doxorubicin-induced neuronal oxidative injury in rats. The rats were treated with CAPE (10 mumol/kg/day i.p.) or saline starting 2 days before a single dose of doxorubicin (20 mg/kg i.p.) or saline. Ten days after the first experiments, the brain was excised to analyze the activities of antioxidant enzymes and levels of malondialdehyde (MDA) and nitric oxide (NO). Doxorubicin alone resulted in higher MDA level in brain tissue than the other groups. The activity of catalase was higher in doxorubicin plus CAPE group than doxorubicin group. There were no significant differences in NO level, glutathione peroxidase (GSH-Px) and superoxide dismutase activities between the groups. There were negative correlations between GSH-Px activity and MDA level in both doxorubicin and doxorubicin plus CAPE groups. It can be concluded that doxorubicin induced oxidant injury can be prevented by CAPE treatment through its antioxidant properties in rat brain.en_US
dc.identifier.doi10.1002/nrc.10089
dc.identifier.endpage138en_US
dc.identifier.issn0893-6609
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0242696115en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage132en_US
dc.identifier.urihttps://doi.org/10.1002/nrc.10089
dc.identifier.urihttps://hdl.handle.net/11616/93661
dc.identifier.volume33en_US
dc.identifier.wosWOS:000186378700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofNeuroscience Research Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdoxorabicinen_US
dc.subjectneurotoxicityen_US
dc.subjectCAPEen_US
dc.subjectantioxidant enzymesen_US
dc.subjectlipid peroxidationen_US
dc.subjectbrainen_US
dc.titleEffects of caffeic acid phenethyl ester against doxorubicin-induced neuronal oxidant injuryen_US
dc.typeArticleen_US

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