Investigation of Lead Mobilization from the Buckshot Residues to the Critical Organs

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dc.authoridBATI, Fatih/0000-0003-3241-6417
dc.authorwosidOzdemir, Bora/B-6655-2013
dc.authorwosidCelbiş, Osman/ABE-2803-2021
dc.contributor.authorCelbis, Osman
dc.contributor.authorKarakoc, Yunus
dc.contributor.authorOzdemir, Bora
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorCakina, Suat
dc.date.accessioned2024-08-04T20:35:35Z
dc.date.available2024-08-04T20:35:35Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractLead exposure causes neurotoxicity, reproductive system dysfunction, renal failure, and blood and endocrine system disorders in human and experimental animals. In this study, we investigated lead mobilization from gunshot fragments to the critical organs (brain, heart, liver, and kidney) and its interaction with essential trace elements on experimental rat model. Thirty-five rats were randomly divided in five groups. The first group was a control and the others were subjected to buckshot implantation in their skeletal muscles (second and third groups) and abdomen (fourth and fifth groups). The control group and the second and fourth groups were sacrificed 1 month after the onset of experiment while the third and fifth groups were followed after 2 months. Blood lead levels were significantly elevated in both 2 month-followed groups and 1 month-followed intraabdominal group. There were significant increases in brain lead levels of both 2 month-followed groups. For the 1 month-followed groups, kidney lead levels were also significantly higher than those of controls. Results show that lead mobilizes from the buckshot residues in distance tissues to the critical organs and interacts with iron, copper, and zinc even though blood lead level sometimes remains unchanged. Our findings are crucial in revealing lead accumulation in critical organs of subjects carrying any gunshot fragments. These subjects and physicians should be in alert for emergence of lead-induced manifestations.en_US
dc.identifier.doi10.1007/s12011-010-8907-7
dc.identifier.endpage694en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue2en_US
dc.identifier.pmid21120706en_US
dc.identifier.scopus2-s2.0-80054739816en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage688en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-010-8907-7
dc.identifier.urihttps://hdl.handle.net/11616/95461
dc.identifier.volume143en_US
dc.identifier.wosWOS:000295609300009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGunshoten_US
dc.subjectLead toxicityen_US
dc.subjectTrace element interactionen_US
dc.subjectCritical organsen_US
dc.subjectForensic scienceen_US
dc.titleInvestigation of Lead Mobilization from the Buckshot Residues to the Critical Organsen_US
dc.typeArticleen_US

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