Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients

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dc.authoridGogas Yavuz, Dilek/0000-0002-0075-6313
dc.authoridSahin, Ibrahim/0000-0002-6231-0034
dc.authoridYüksel, Meral/0000-0002-4760-3306
dc.authoridkeskin, lezan/0000-0001-8283-4516;
dc.authorwosidSert, Murat/G-6103-2018
dc.authorwosidGogas Yavuz, Dilek/GRR-7277-2022
dc.authorwosidSahin, Ibrahim/ABI-6050-2020
dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.authorwosidYüksel, Meral/Z-3692-2019
dc.authorwosidkeskin, lezan/HJP-0902-2023
dc.authorwosiddeyneli, oguzhan/JDN-0554-2023
dc.contributor.authorYavuz, Dilek Gogas
dc.contributor.authorKeskin, Lezan
dc.contributor.authorKiyici, Sinem
dc.contributor.authorSert, Murat
dc.contributor.authorYazici, Dilek
dc.contributor.authorSahin, Ibrahim
dc.contributor.authorYuksel, Meral
dc.date.accessioned2024-08-04T20:35:41Z
dc.date.available2024-08-04T20:35:41Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPrevious studies have suggested an influence of vitamin D receptor alleles on bone metabolism and on susceptibility to type 1 diabetes mellitus in different ethnic populations. We aimed to investigate the distribution of vitamin D receptor (VDR) alleles in relation to biochemical bone turnover parameters and bone densitometry measurements in a group of Turkish type 1 diabetic patients. One hundred and seventeen patients (M/F 57/60, 27.6 +/- A 7.3 y duration of diabetes 8.1 +/- A 6.3 y) and 134 healthy controls (M/F 61/73, 26.2 +/- A 5.3 y) were included in the study. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorptiometry (DEXA). The vitamin D receptor gene (VDR) polymorphisms FokI, Bsm1, Apa1, and Taq1 were examined using a PCR-based restriction analysis. Serum levels of calcium, phosphor osteocalcin, intact parathyroid hormone, and C telopeptide were measured. Vitamin D receptor Bsm1 Fok1, Apa1, and Taq1 genotype distributions were not different between patient with diabetes and control groups. BMD was 0.77 +/- A 0.2 g/cm(2) vs. 0.97 +/- A 0.2 g/cm(2) (P = 0.0001) for the femur, 1.0 +/- A 0.1 g/cm(2) vs. 1.13 +/- A 0.1 g/cm(2) (P = 0.001) for type 1 diabetic patients and controls. Bone turnover markers were significantly lower in type 1 diabetic group. BMD measurements and bone metabolic markers were not different between the genotypes in either the patient with diabetes or the controls. The VDR gene polymorphisms, Bsm1, Fok 1, Apa1, and Taq1 showed no influence on bone metabolism in our group of type 1 diabetic patients.en_US
dc.description.sponsorshipTurkish Diabetes foundationen_US
dc.description.sponsorshipThis study supported by a grant from Turkish Diabetes foundation.en_US
dc.identifier.doi10.1007/s00592-011-0284-y
dc.identifier.endpage336en_US
dc.identifier.issn0940-5429
dc.identifier.issn1432-5233
dc.identifier.issue4en_US
dc.identifier.pmid21538164en_US
dc.identifier.scopus2-s2.0-84355166778en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage329en_US
dc.identifier.urihttps://doi.org/10.1007/s00592-011-0284-y
dc.identifier.urihttps://hdl.handle.net/11616/95516
dc.identifier.volume48en_US
dc.identifier.wosWOS:000297515600009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofActa Diabetologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectType 1 diabetesen_US
dc.subjectVitamin Den_US
dc.subjectVitamin D receptor gene polymorphismsen_US
dc.subjectBone mineral densityen_US
dc.titleVitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patientsen_US
dc.typeArticleen_US

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