Nasopharyngeal carcinomas

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dc.authorwosidErkal, Haldun Sukru/AAC-8209-2019
dc.contributor.authorErkal, HS
dc.contributor.authorSerin, M
dc.contributor.authorÇakmak, A
dc.date.accessioned2024-08-04T20:12:17Z
dc.date.available2024-08-04T20:12:17Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The present study reviews the experience in treatment of 447 patients with nasopharyngeal carcinomas, analyzing patient, tumor and treatment characteristics determining outcome. Materials and methods: There were 322 males and 125 females, their ages ranging from 7 to 85 years (median, 45 years). Two-hundred and seventy-two patients had World Health Organization (WHO) type 3 carcinomas, 123 patients had T4 tumors and 320 patients had metastatic cervical lymph nodes. Three-hundred and eight patients were treated with radiation therapy alone and 139 patients with chemotherapy in combination with radiation therapy. Cumulative radiation dose to primary tumor ranged from 50 to 76 Gy (median, 70 Gy) and radiation dose to metastatic cervical lymph nodes ranged. from 46 to 74 Gy (median, 66 Gy). Results: Follow-up ranged from 0.1 to 19.5 years (mean, 7.6 years). Local complete response was achieved in 357 patients. In multivariate analysis, T-classification, cumulative radiation dose to primary tumor and treatment with chemotherapy in combination with radiation therapy predicted local response. Nodal complete response was achieved in 272 patients. In multivariate analysis, N-classification and radiation dose to metastatic cervical lymph nodes predicted nodal response. Local failure was observed in 70 patients, nodal failure in 35 patients and systemic failure in 114 patients. Overall survival, disease-free survival and disease-specific survival were 33, 32 and 37%, respectively, at 10 years. In multivariate analysis, age, T-classification, N-classification, radiation dose and treatment with chemotherapy in combination with radiation therapy predicted overall survival whereas T-classification. N-classification, radiation dose and treatment with chemotherapy in combination with radiation therapy predicted both disease-free survival and disease-specific survival. Conclusions: Radiation therapy alone appears to be an adequate and viable treatment for patients with early-stage nasopharyngeal carcinomas, whereas treatment with chemotherapy in combination with radiation therapy appears to improve outcome for patients with advanced-stage nasopharyngeal carcinomas. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S0167-8140(01)00448-0
dc.identifier.endpage256en_US
dc.identifier.issn0167-8140
dc.identifier.issue3en_US
dc.identifier.pmid11730993en_US
dc.identifier.scopus2-s2.0-0035204898en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage247en_US
dc.identifier.urihttps://doi.org/10.1016/S0167-8140(01)00448-0
dc.identifier.urihttps://hdl.handle.net/11616/93327
dc.identifier.volume61en_US
dc.identifier.wosWOS:000172965400004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofRadiotherapy and Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnasopharynxen_US
dc.subjectcarcinomaen_US
dc.subjectradiotherapyen_US
dc.subjectchemotherapyen_US
dc.titleNasopharyngeal carcinomasen_US
dc.typeArticleen_US

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