Serum nitric oxide levels in patients with head and neck squamous cell carcinoma.

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dc.authorscopusid6603956791
dc.authorscopusid6602540278
dc.authorscopusid6602542598
dc.authorscopusid6701831814
dc.authorscopusid12242496000
dc.authorscopusid7003373872
dc.authorscopusid7006625363
dc.contributor.authorKizilay A.
dc.contributor.authorKalcio?lu M.T.
dc.contributor.authorOzu?urlu F.
dc.contributor.authorOzyurt H.
dc.contributor.authorAlada? I.
dc.contributor.authorOzturan O.
dc.contributor.authorAkyol O.
dc.date.accessioned2024-08-04T20:01:09Z
dc.date.available2024-08-04T20:01:09Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVES: We determined serum nitric oxide (NO) levels in patients with head and neck squamous cell carcinoma (SCC) and sought correlations with TNM staging, tumor localization, and tumor grade. PATIENTS AND METHODS: Serum samples were obtained from 36 patients (mean age 63 years; range 37 to 80 years) with head and neck SCC prior to treatment and from 20 healthy individuals (mean age 56 years; range 30 to 72 years) as controls. Tumor staging was based on the criteria of the American Joint Committee of Cancer staging system in 2002. Thirteen patients had stage I-II, and 23 patients had stage III-IV tumors and all had well- or moderately-differentiated SCC (grade 1-2). Serum NO levels were analyzed by a spectrophotometric method based on the determination of total nitrite levels in serum and compared between the patient and control groups. RESULTS: The mean serum NO levels were 20.08+/-1.40 micromol/l and 13.57+/-0.99 micromol/l in cancer patients and controls, respectively (p=0.001). There were no correlations between NO levels and age, sex, tumor stage, localization, and histological grade. CONCLUSION: These data suggest that head and neck SCC is associated with increased serum NO levels, which may play a role in tumor growth.en_US
dc.identifier.endpage151en_US
dc.identifier.issn1300-7475
dc.identifier.issue3en_US
dc.identifier.pmid17873505en_US
dc.identifier.scopus2-s2.0-34948815594en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage148en_US
dc.identifier.urihttps://hdl.handle.net/11616/91289
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofKulak burun bo?az ihtisas dergisi : KBB = Journal of ear, nose, and throaten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnitric oxideen_US
dc.subjecttumor markeren_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectarticleen_US
dc.subjectblooden_US
dc.subjectcancer stagingen_US
dc.subjectcase control studyen_US
dc.subjectevaluationen_US
dc.subjectfemaleen_US
dc.subjecthead and neck tumoren_US
dc.subjecthumanen_US
dc.subjectmaleen_US
dc.subjectmiddle ageden_US
dc.subjectpathologyen_US
dc.subjectprediction and forecastingen_US
dc.subjectsquamous cell carcinomaen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectCarcinoma, Squamous Cellen_US
dc.subjectCase-Control Studiesen_US
dc.subjectFemaleen_US
dc.subjectHead and Neck Neoplasmsen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectNeoplasm Stagingen_US
dc.subjectNitric Oxideen_US
dc.subjectPredictive Value of Testsen_US
dc.subjectTumor Markers, Biologicalen_US
dc.titleSerum nitric oxide levels in patients with head and neck squamous cell carcinoma.en_US
dc.typeArticleen_US

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