Low-grade Epithelial-Myoepithelial Carcinoma of Bartholin Gland: Report of 2 Cases of a Distinctive Neoplasm Arising in the Vulvovaginal Region

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dc.authoridAYDIN, Nasuhi/0000-0003-3145-2432
dc.authoridWong, Newton/0000-0002-9537-4106
dc.authorwosidAydin, Nasuhi E/B-6536-2012
dc.authorwosidAYDIN, Nasuhi Engin/L-1607-2019
dc.authorwosidAYDIN, Nasuhi/O-9043-2016
dc.contributor.authorMcCluggage, W. Glenn
dc.contributor.authorAydin, N. Engin
dc.contributor.authorWong, Newton A. C. S.
dc.contributor.authorCooper, Kumarasen
dc.date.accessioned2024-08-04T20:31:17Z
dc.date.available2024-08-04T20:31:17Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe report 2 cases of a distinctive neoplasm arising from Bartholin gland and presenting as a vulval or vaginal mass. The tumors occurred in patients aged 44 and 51 years and were 2 and 3 cm in maximum dimension. In both cases, normal Bartholin gland tissue was identified adjacent to the lesion. The neoplasms were unencapsulated and largely well circumscribed but with a focally infiltrative edge. They were composed of tubular, trabecular, or insular arrangements with a double layer of inner cuboidal cells with round nuclei and outer cells with ovoid nuclei and clear cytoplasm, corresponding to epithelial and myoepithelial cells, respectively. Luminal eosinophilic colloid-like material was present. In both cases.. a minor proportion of the neoplasm consisted of cribriform arrangements, creating an appearance reminiscent of adenoid cystic carcinoma, although the overall morphology was not typical of that lesion. Mitotic figures were identified in both cases, the mitotic count being 1 and 5/10 high-power fields. Immunohistochemically, the inner cells were positive with epithelial markers. including broad-spectrum cytokeratins and epithelial membrane antigen, and the outer cell layer was positive with myoepithelial markers p63, calponin, and alpha-smooth muscle actin. Both neoplasms exhibited diffuse strong immunoreactivity of the epithelial cells with c-kit. Activating mutations in KIT exons 9, 11, 13, and 17 and in platelet-derived growth factor receptor alpha exons 12, 14, and 18 were searched for by polymerase chain reaction and direct sequencing but were not identified. We believe this represents a low-grade carcinoma arising from Bartholin gland composed of a dual population of epithelial and myoepithelial cells and closely resembling the salivary gland neoplasm termed epithelial-myoepithelial carcinoma. We propose the term low-grade epithelial-myoepithelial carcinoma of Bartholin gland.en_US
dc.identifier.doi10.1097/PGP.0b013e31818e1040
dc.identifier.endpage291en_US
dc.identifier.issn0277-1691
dc.identifier.issue3en_US
dc.identifier.pmid19620948en_US
dc.identifier.scopus2-s2.0-69049101100en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage286en_US
dc.identifier.urihttps://doi.org/10.1097/PGP.0b013e31818e1040
dc.identifier.urihttps://hdl.handle.net/11616/94855
dc.identifier.volume28en_US
dc.identifier.wosWOS:000265438600012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofInternational Journal of Gynecological Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVulvaen_US
dc.subjectVaginaen_US
dc.subjectBartholin glanden_US
dc.subjectCarcinomaen_US
dc.subjectEpithelial-myoepithelial carcinomaen_US
dc.subjectImmunohistochemistryen_US
dc.titleLow-grade Epithelial-Myoepithelial Carcinoma of Bartholin Gland: Report of 2 Cases of a Distinctive Neoplasm Arising in the Vulvovaginal Regionen_US
dc.typeArticleen_US

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