Synthesis, characterization and antimicrobial properties of p-nitrobenzyl-substituted N-heterocyclic carbene silver, ruthenium and palladium complexes
Küçük Resim Yok
Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The ruthenium, palladium, and silver complexes with N-heterocyclic carbene (NHC) ligands have been widely studied for promising anticancer activities, and they have been found to exhibit strong cytotoxic activity toward a range of cancer cells. However, the ruthenium and palladium NHC complexes have been less studied compared to silver and gold NHC complexes as antimicrobial agents. Herein, Ag, Ru, and Pd complexes of a benzimidazol-2-ylidene ligand bearing p-nitrobenzyl and diisopropylaminoethyl groups were synthesized and characterized by FT-IR, H-1 NMR and C-13 NMR spectroscopy, elemental analysis and mass spectrometry. The molecular and crystal structures of 2 and 4 were confirmed by the single-crystal X-ray diffraction (SC-XRD) method. All compounds were tested for antibacterial and antifungal activities and the minimum inhibitory concentrations were determined. The results indicates that some compounds exert effective antibacterial activity against Gram-negative and four Gram-positive bacterial strains and two yeast strains. Ag complex 2 had great antibacterial activity against Staphylococcus aureus at MIC value of 12.5 mu g/mL. However, the presence of ruthenium in the structure of the compounds increased overall antibacterial and antifungal activity.
Açıklama
Anahtar Kelimeler
N -heterocyclic carbene, Silver, Ruthenium, Palladium, Antimicrobial
Kaynak
Polyhedron
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
281
