Conjunctival impression cytology and tear-film changes in cases with vitamin D deficiency

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dc.authoridAKATLI, AYSE NUR/0000-0002-9677-2456;
dc.authorwosiddikci, seyhan/A-3311-2019
dc.authorwosidAKATLI, AYSE NUR/ABH-4455-2020
dc.authorwosidYildirim, Tulay/AAB-5030-2021
dc.contributor.authorDikci, Seyhan
dc.contributor.authorAkatli, Ayse Nur
dc.contributor.authorYildirim, Tulay
dc.date.accessioned2024-08-04T20:47:13Z
dc.date.available2024-08-04T20:47:13Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose To evaluate conjunctival surface cells and tear-film functions in cases with vitamin D deficiency. Methods Thirty-six patients with serum vitamin D deficiency and 27 control subjects with normal serum vitamin D levels were included in this prospective study. The tear break-up time (TBUT), Schirmer II test, and conjunctival impression cytology tests were performed to all participants. Results The mean serum vitamin D levels were 10.5 +/- 5.0 mu l in the study group and 33.9 +/- 11.7 mu l in the control group (p < 0.001). The median TBUT scores were 11 s and 17 s and the median Schirmer II values were 7.5 mm and 12 mm in the study and the control groups, respectively (p = 0.003, p = 0.049). According to the Nelson staging system, 69.4% of the patients in the study group had grade 2 or 3 impression cytology, whereas 18.5% of the participants in the control group had grade 2 or 3 impression cytology (p < 0.001). Conclusion Our study results showed that vitamin D deficiency may lead to dry eye causing conjunctival squamous metaplasia and loss of goblet cells on the ocular surface.en_US
dc.identifier.doi10.1007/s10792-020-01336-1
dc.identifier.endpage1694en_US
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue7en_US
dc.identifier.pmid32207046en_US
dc.identifier.scopus2-s2.0-85082191387en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1687en_US
dc.identifier.urihttps://doi.org/10.1007/s10792-020-01336-1
dc.identifier.urihttps://hdl.handle.net/11616/99231
dc.identifier.volume40en_US
dc.identifier.wosWOS:000521717300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConjunctival impression cytologyen_US
dc.subjectDry eyeen_US
dc.subjectVitamin D deficiencyen_US
dc.subjectTear break-up timeen_US
dc.subjectSchirmer testen_US
dc.titleConjunctival impression cytology and tear-film changes in cases with vitamin D deficiencyen_US
dc.typeArticleen_US

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