The effect of adrenomedullin on rats exposed to lead

Basit Öğe Kaydı
dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoriderdogan, selim/0000-0002-9169-9771
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosiderdogan, selim/AAT-2487-2020
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.contributor.authorDogru, Mehmet Ker
dc.contributor.authorDogru, Arzu Kocagun
dc.contributor.authorGul, Mehmet
dc.contributor.authorEsrefoglu, Mukaddes
dc.contributor.authorYurekli, Muhittin
dc.contributor.authorErdogan, Selim
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:30:44Z
dc.date.available2024-08-04T20:30:44Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAdrenomedullin (AdM) was originally discovered as a vasorelaxant peptide. The antioxidative properties of AdM have been reported recently. Through its antioxidative effect, adrenomedullin can protect organs from damage induced by stressors. Lead, commonly detected in air, soil, water and food, is a major source of oxidative stress. The effect of AdM in the liver of rats exposed to lead was investigated. Twenty-four female Wistar rats were divided into four groups: a control group (C), adrenomedullin group (AdM), lead (Pb) group and lead + adrenomedullin (Ph + AdM) group. In the Pb-treated groups, the animals were exposed to lead in drinking water containing 250 ppm PbCl2 for 4 weeks. In the AdM-treated group, the animals received an i.p. injection of AdM (3000 ng kg(-1) body weight) in the third week of lead treatment for I week. The activities of catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) and the level of malondialdehyde (NIDA) were determined in the liver of rats. Histological changes in the liver were examined by light and electron microscopy as well. The NIDA levels were increased significantly in the Pb-treated groups, but in the Ph + AdM group the NIDA levels were decreased significantly when compared with the Ph group. AdM reduced hepatic damage in the Pb + AdM group, but the difference in the total histopathological scores between the Pb and Ph + AdM groups was not significant. When the results are taken together, it can be concluded that AdM may have protective or compensating effects in lead toxicity. Copyright (c) 2007 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/jat.1259
dc.identifier.endpage146en_US
dc.identifier.issn0260-437X
dc.identifier.issn1099-1263
dc.identifier.issue2en_US
dc.identifier.pmid17503410en_US
dc.identifier.scopus2-s2.0-41149173222en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage140en_US
dc.identifier.urihttps://doi.org/10.1002/jat.1259
dc.identifier.urihttps://hdl.handle.net/11616/94489
dc.identifier.volume28en_US
dc.identifier.wosWOS:000254212600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Applied Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectantioxidant enzymesen_US
dc.subjecthistologyen_US
dc.subjectleaden_US
dc.subjectlipid peroxidationen_US
dc.subjectoxidative stressen_US
dc.subjectpathologyen_US
dc.subjectultrastructural changesen_US
dc.titleThe effect of adrenomedullin on rats exposed to leaden_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu