Multiplex PCR Detection of Respiratory Tract Infections in SARS-CoV-2-Negative Patients Admitted to the Emergency Department: an International Multicenter Study during the COVID-19 Pandemic

Basit Öğe Kaydı
dc.authorscopusid57946427900
dc.authorscopusid55826114500
dc.authorscopusid8603159200
dc.authorscopusid57226709862
dc.authorscopusid6701605344
dc.authorscopusid57209097150
dc.authorscopusid55203631000
dc.contributor.authorDuclos M.
dc.contributor.authorHommel B.
dc.contributor.authorAllantaz F.
dc.contributor.authorPowell M.
dc.contributor.authorPosteraro B.
dc.contributor.authorSanguinetti M.
dc.contributor.authorHabous M.
dc.date.accessioned2024-08-04T20:03:37Z
dc.date.available2024-08-04T20:03:37Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRespiratory tract infection (RTI) is a common cause of visits to the hospital emergency department. During the ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), nonpharmaceutical intervention has influenced the rates of circulating respiratory viruses. In this study, we sought to detect RTI etiological agents other than SARS-CoV-2 in emergency department patients from 13 countries in Europe, the Middle East, and Africa from December 2020 to March 2021. We sought to measure the impact of patient characteristics and national-level behavioral restrictions on the positivity rate for RTI agents. Using the BioFire Respiratory Panel 2.0 Plus, 1,334 nasopharyngeal swabs from patients with RTI symptoms who were negative for SARS-CoV-2 were tested. The rate of positivity for viral or bacterial targets was 36.3%. Regarding viral targets, human rhinovirus or enterovirus was the most prevalent (56.5%), followed by human coronaviruses (11.0%) and adenoviruses (9.9%). Interestingly, age stratification showed that the positivity rate was significantly higher in the children's group than in the adults' group (68.8% versus 28.2%). In particular, human rhinovirus or enterovirus, the respiratory syncytial virus, and other viruses, such as the human metapneumovirus, were more frequently detected in children than in adults. A logistic regression model was also used to determine an association between the rate of positivity for viral agents with each country's behavioral restrictions or with patients' age and sex. Despite the impact of behavioral restrictions, various RTI pathogens were actively circulating, particularly in children, across the 13 countries. Copyright © 2022 Duclos et al.en_US
dc.identifier.doi10.1128/spectrum.02368-22
dc.identifier.issn2165-0497
dc.identifier.issue5en_US
dc.identifier.pmid36154273en_US
dc.identifier.scopus2-s2.0-85140856065en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1128/spectrum.02368-22
dc.identifier.urihttps://hdl.handle.net/11616/91946
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.ispartofMicrobiology Spectrumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectemergency departmenten_US
dc.subjectmultiplex PCR assayen_US
dc.subjectrespiratory tract infectionen_US
dc.subjectSARS-CoV-2en_US
dc.subjectviral infectionen_US
dc.titleMultiplex PCR Detection of Respiratory Tract Infections in SARS-CoV-2-Negative Patients Admitted to the Emergency Department: an International Multicenter Study during the COVID-19 Pandemicen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu