Engineering hydrogels as extracellular matrix mimics

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dc.authoridGeckil, Hikmet/0000-0003-0070-0691
dc.authoridXu, Feng/0000-0003-4351-0222
dc.authorwosidXu, Feng/C-7430-2011
dc.authorwosidGeckil, Hikmet/F-7647-2012
dc.authorwosidliu, fusheng/J-4815-2014
dc.authorwosidZhang, Xiaohui/C-4569-2013
dc.authorwosidXu, Feng/E-8549-2018
dc.authorwosidZHANG, XIAOHUI/AHA-7028-2022
dc.authorwosidXu, Feng/H-4468-2011
dc.contributor.authorGeckil, Hikmet
dc.contributor.authorXu, Feng
dc.contributor.authorZhang, Xiaohui
dc.contributor.authorMoon, SangJun
dc.contributor.authorDemirci, Utkan
dc.date.accessioned2024-08-04T20:32:22Z
dc.date.available2024-08-04T20:32:22Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractExtracellular matrix (ECM) is a complex cellular environment consisting of proteins, proteoglycans, and other soluble molecules. ECM provides structural support to mammalian cells and a regulatory milieu with a variety of important cell functions, including assembling cells into various tissues and organs, regulating growth and cell cell communication. Developing a tailored in vitro cell culture environment that mimics the intricate and organized nanoscale meshwork of native ECM is desirable. Recent studies have shown the potential of hydrogels to mimic native ECM. Such an engineered native-like ECM is more likely to provide cells with rational cues for diagnostic and therapeutic studies. The research for novel biomaterials has led to an extension of the scope and techniques used to fabricate biomimetic hydrogel scaffolds for tissue engineering and regenerative medicine applications. In this article, we detail the progress of the current state-of-the-art engineering methods to create cell-encapsulating hydrogel tissue constructs as well as their applications in in vitro models in biomedicine.en_US
dc.description.sponsorshipJ William Fulbright Foundation; Fulbright Scholar at the BAMM Labs; Center for Biomedical Engineering; Brigham and Women's Hospital (MA, USA); Harvard Medical School; NIH [R21-EB007707]; Randolph Hearst Foundationen_US
dc.description.sponsorshipHikmet Geckil gratefully acknowledges the support of the J William Fulbright Foundation, as a Fulbright Scholar at the BAMM Labs, Center for Biomedical Engineering, Brigham and Women's Hospital (MA, USA), Harvard Medical School.; This work was partially supported by the NIH-R21-EB007707 and the Randolph Hearst Foundation, Brigham and Women's Hospital Department of Medicine Young Investigator in Medicine Award. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.en_US
dc.identifier.doi10.2217/NNM.10.12
dc.identifier.endpage484en_US
dc.identifier.issn1743-5889
dc.identifier.issn1748-6963
dc.identifier.issue3en_US
dc.identifier.pmid20394538en_US
dc.identifier.scopus2-s2.0-77951218278en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage469en_US
dc.identifier.urihttps://doi.org/10.2217/NNM.10.12
dc.identifier.urihttps://hdl.handle.net/11616/95023
dc.identifier.volume5en_US
dc.identifier.wosWOS:000277074000015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFuture Medicine Ltden_US
dc.relation.ispartofNanomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbiopatterningen_US
dc.subjectcell-encapsulating microfluidic hydrogelsen_US
dc.subjectcell microenvironmenten_US
dc.subjectextracellular matrixen_US
dc.subjecttissue engineeringen_US
dc.titleEngineering hydrogels as extracellular matrix mimicsen_US
dc.typeReview Articleen_US

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